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(11)

2 437 886

(13)

(51)

IPC

C07D487/04(2006-01-01)

C07D401/14(2006-01-01)

A61K31/4725(2006-01-01)

A61P31/14(2006-01-01)

(21) (22)

Application

2008107727/04, 2006-07-28

(24)

Start date

2006-07-28

(22)

Actual filing date

2006-07-28

(45)

Published

2011-12-27

(72)

Inventor

Rabuasson P'Er Zhan-Mari BernarDe Kok Kherman AugustinusDoranzh IsmetVendevill' Sandrin Mari EhlenSjurlero Dominik Lui Nestor GilehjnTakhri AbdellakhSimonne IvanVan De Frejken VimKhu LiliSimmen Kennet AlanNil'Sson Karl MagnusSamuehl'Sson Bengt BertilRosenkvist Osa Annika KristinaVall'Berg Khans Kristian

(73)

Holder

Tibotek Farmas'Jutikalz Ltd.Medivir Ab

MACROCYCLIC HEPATITIS C VIRUS INIHBITORS Russian patent published in 2011 - IPC C07D487/04 C07D401/14 A61K31/4725 A61P31/14

Abstract RU 2437886 C2

FIELD: chemistry.

SUBSTANCE: invention describes novel macrocyclic compounds of formulae pharmaceutically acceptable salts or stereoisomers thereof, where R¹ = -OR⁵, -NH-SO₂R⁶; R²= hydrogen; R³ = C_1-6-alkyl; R⁴ = isoquinolinyl, possibly substituted; n equals 4 or 5; R⁵ = hydrogen; R⁶ = C_3-7-cycloalkyl, and a pharmaceutical composition containing said compounds.

EFFECT: novel compounds have hepatitis C virus replication inhibitory action and can be used in medicine.

6 cl, 32 ex, 1 tbl

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RU 2 437 886 C2

Authors

Rabuasson P'Er Zhan-Mari Bernar

De Kok Kherman Augustinus

Doranzh Ismet

Vendevill' Sandrin Mari Ehlen

Sjurlero Dominik Lui Nestor Gilehjn

Takhri Abdellakh

Simonne Ivan

Van De Frejken Vim

Khu Lili

Simmen Kennet Alan

Nil'Sson Karl Magnus

Samuehl'Sson Bengt Bertil

Rosenkvist Osa Annika Kristina

Vall'Berg Khans Kristian

Dates

2011-12-27—Published

2006-07-28—Filed