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(11)

2 436 787

(13)

(51)

IPC

C07D487/04(2006-01-01)

C07D403/04(2006-01-01)

A61K31/41(2006-01-01)

A61P31/14(2006-01-01)

(21) (22)

Application

2008107726/04, 2006-07-28

(24)

Start date

2006-07-28

(22)

Actual filing date

2006-07-28

(45)

Published

2011-12-20

(72)

Inventor

Rabuasson P'Er Zhan-Mari BernarDe Kok Kherman AugustinusVan De Frejken VimSjurlero Dominik Lui Nestor GilehjnSimmen Kennet Alan

(73)

Holder

Tibotek Farmas'Jutikalz Ltd.

MACROCYCLIC HEPATITIS C INHIBITORS Russian patent published in 2011 - IPC C07D487/04 C07D403/04 A61K31/41 A61P31/14

Abstract RU 2436787 C2

FIELD: chemistry.

SUBSTANCE: invention describes novel macrocyclic compounds of general formulae (I-c) (I-d), pharmaceutically acceptable salt or stereoisomer thereof, where R¹ = -OR¹¹ or -NH-SO₂R¹²; R² = hydrogen and R³ =C_1-6-alkyl; n = 3-6; W is a radical of formula , where R⁵ = phenyl, possibly substituted with C_1-6alkyl or alkoxy; thiazolyl, possibly substituted with C_1-6alkyl; or pyridyl; R¹¹ denotes hydrogen; R¹² = C_3-7-cycloalkyl, and a pharmaceutical composition containing said compounds.

EFFECT: said compounds are hepatitis C virus inhibitors and can be used in medicine.

3 cl, 6 ex

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RU 2 436 787 C2

Authors

Rabuasson P'Er Zhan-Mari Bernar

De Kok Kherman Augustinus

Van De Frejken Vim

Sjurlero Dominik Lui Nestor Gilehjn

Simmen Kennet Alan

Dates

2011-12-20—Published

2006-07-28—Filed