GLUCAN COMPOSITIONS Russian patent published in 2013 - IPC C08B37/00 C12P19/00 C07H5/06 

FIELD: chemistry.

SUBSTANCE: group of inventions relates to biochemistry. Disclosed is a composition, having immune-stimulating properties, which contains unmodified, soluble β-glucan with average molecular weight from about 120000 Da to about 205000 Da. The composition also contains soluble β-glucan with molecular weight greater than 380000 Da in amount of less than or equal to 10% and β-glucan with molecular weight of less than 25000 Da in amount of less than or equal to 17%. The unmodified, soluble β-glucan can be used in single doses of up to about 6 mg/kg. Also disclosed is a method of producing soluble β-glucan. The method involves applying pressure of up 35 lb/in² (24607.4 kg/m²) to a suspension of powdered β-glucan and an acid. The suspension is then heated to 135°C for a period of time which is sufficient to form soluble β-glucan. Also disclosed are compositions (versions), having immune-stimulating properties, which contain a pharmaceutically effective amount of unmodified, soluble β-glucan obtained using said method.

EFFECT: invention enables to obtain improved β-glucan compositions, which can be administered in a higher concentration than the maximum dose with fewer undesirable reactions.

28 cl, 4 tbl, 2 dwg