PLASMAPHERESIS PROCEDURE IN SINGLE-NEEDLE EXTRACORPOREAL CIRCUIT AND DEVICE FOR IMPLEMENTATION THEREOF Russian patent published in 2013 - IPC A61M1/36 

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, namely to efferent therapy, and may be used for carrying out the plasmapheresis procedures. What is presented is a device consisting of a blood sampling and return unit, a blood exfusion line, a blood re-infusion line, an anticoagulant and diluent feed line, a plasma bleed line, a pressure measurement line. Return valves are provided in the blood exfusion and re-infusion lines, anticoagulant and diluent feed line, and plasma bleed line. The first return valve is fixed either in a tube of the blood exfusion line or in an input fitting of a pump segment. The second return valve is fixed either in a tube the blood re-infusion line or in an output fitting of the pump segment. The third, fourth and fifth ones accompany tubes of the anticoagulant and diluent feed line and bleed plasma line. The anticoagulant feed line and blood exfusion line are coupled in front of the first return valve or thereafter. The diluent feed line is coupled with the blood exfusion line in front of the first return valve or thereafter or coupled with the blood re-infusion line in front of the second return valve or thereafter A pump segment chamber made of an elastic material is provided between a fixed and movable plate coupled with a mechanism of its reciprocation limited by stop pieces with integrated pump level and empty sensors. The chamber fill-in volume preferentially falls within the range of 2 to 20 ml. When extended, the chamber negative pressure makes 50 to 150 mm Hg. The movable plate has the variation along the thickness, while a motion mechanism of the movable plate is electrically connected to the pressure sensor, as well as to the pump level and empty sensors. Some tubes of the anticoagulant and/or diluent feed lines fall down in case of pressure drop and movable through an external pinch tube valve or a slot unit with the variation along slot width which specifies a dose ratio of anticoagulant/blood and/or diluent/blood in the range preferentially from 1:4 to 1:48. A pressure propagation line extends through the external pinch tube valve which is electrically connected to the pump level and empty sensors. What is presented is a plasmapheresis procedure in a single-needle extracorporeal circuit involving the stage of blood exfusion and the stage of blood re-infusion. A portion of blood, a dose of the anticoagulant and/or diluent are introduced into the pump segment chamber pre-compressed at the stage of re-infusion. The exfusate volume is specified with limiting a degree of extension of the pump segment chamber. A dose of the anticoagulant and/or diluent is administered uniformly for the entire stage of exfusion in equal portions from the desired containers, or introduced immediately for the entire stage or a part thereof as a one portion from falling down volume-adjustable tanks. In the beginning of the stage of re-infusion, anticoagulant and/or diluent are blocked from backflow into the falling down tanks and/or their container, while exfusate and plasma are blocked from backflow into vein and plasmofilter, respectively. Plasma is separated at constant plasmofilter inlet pressure with the pressure level maintained by adjusting a compression speed of the pump segment chamber by means of a feedback signal supplied from the pressure measurement line in front of the plasmafilter, blocked at the stage of exfusion and opened at the stage of reinfusion. Before the end of the stage of reinfusion, at the moment of maximum contraction of the pump segment chamber, the stage of exfusion starts.

EFFECT: invention provides single plasma sampling with enabled uniform anticoagulant and/or diluent feed simultaneously with the stage of blood exfusion ensured by the optimised control of the procedure parameters with maintained sterility of the extracorporeal circuit.

20 cl, 7 dwg