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2 492 166

(13)

(51)

IPC

C07D401/12(2006-01-01)

C07D401/14(2006-01-01)

C07D403/12(2006-01-01)

C07D403/14(2006-01-01)

C07D413/14(2006-01-01)

C07D417/12(2006-01-01)

C07D417/14(2006-01-01)

C07D487/04(2006-01-01)

A61K31/506(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2009149214/04, 2008-06-30

(24)

Start date

2008-06-30

(22)

Actual filing date

2008-06-30

(45)

Published

2013-09-10

(72)

Inventor

Chehn' VehjzhunKossrou DzhenniferFranklin LlojdGuan' BinDzhounz Dzhon KhovardKumaravel GnanasambandamLehjn BendzhaminLittke AdamLugovskoj AleksejPehn KhajzhoPauehll Noehl'Rajmundo BrajanTanaka KhirokoVesselz DzheffriUinn TomasSin' Chzhili

(73)

Holder

Sanesis Farmas'Jutikalz, Ink.Bajodzhen Ajdek Ma Ink.

COMPOUNDS SUITABLE FOR USE AS RAF KINASE INHIBITORS Russian patent published in 2013 - IPC C07D401/12 C07D401/14 C07D403/12 C07D403/14 C07D413/14 C07D417/12 C07D417/14 C07D487/04 A61K31/506 A61P35/00

Abstract RU 2492166 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula 1:

or pharmaceutically acceptable salts thereof, where values of Cy¹; Cy²; L¹; L², R; R¹; R^x and R^y and R² are given in claim 1.

EFFECT: compounds are suitable for use as Raf protein kinase inhibitors.

36 cl, 6 tbl

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RU 2 492 166 C2

Authors

Chehn' Vehjzhun

Kossrou Dzhennifer

Franklin Llojd

Guan' Bin

Dzhounz Dzhon Khovard

Kumaravel Gnanasambandam

Lehjn Bendzhamin

Littke Adam

Lugovskoj Aleksej

Pehn Khajzho

Pauehll Noehl'

Rajmundo Brajan

Tanaka Khiroko

Vesselz Dzheffri

Uinn Tomas

Sin' Chzhili

Dates

2013-09-10—Published

2008-06-30—Filed