HETEROARYL COMPOUNDS AND USING THEM Russian patent published in 2014 - IPC C07D239/48 C07D401/12 C07D401/14 C07D403/12 C07D403/14 C07D405/12 C07D405/14 C07D407/12 C07D413/12 C07D413/14 C07D417/14 C07D471/04 C07D487/04 A61K31/505 A61K31/506 A61K31/538 A61K31/5377 A61P35/00 A61P37/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds of structural formula

possessing inhibitory activity on BTK, TEC, BMX, ITK, ErbB1, ErbB4 and/or JAK3 kinases. In formula (I-b), ring A and ring B represents phenyl; R^y represents -CN, -CF₃, C_1-4 aliphatic group, C_1-4 halogenaliphatic group, -OR, -C(O)R or -C(O)N(R)₂; each group R independently represents hydrogen or a group specified in C_1-6 aliphatic group optionally containing a substitute presented by halogen, -(CH₂)_0-4R°, -(CH₂)_0-4OR°, -(CH₂)_0-4N(R°)₂, -(CH₂)_0-4N(R°)C(O)OR°, -(CH₂)_0-4C(O)R°, -(CH₂)_0-4S(O)₂R°, or 5-6-merous substituted or aryl ring containing 1-2 heteroatoms independently specified in nitrogen or oxygen optionally substituted by group =O, -(CH₂)_0-4R°, -(CH₂)_0-4N(R°)₂ or -(CH₂)_0-4OR°; phenyl; 5-6-merous heterocyclic ring containing 1-2 heteroatoms independently specified in nitrogen, oxygen or sulphur optionally substituted by group -(CH₂)_0-4R°, -(CH₂)_0-4OR° or =O; or 6-merous monocyclic heteroaryl ring containing 1 nitrogen atom; W¹ and W² represent -NR²-; R² represents hydrogen, C_1-6aliphatic group or -C(O)R; m and p are independently equal to 0, 1, 2, 3 or 4; R^x is independently specified in -R, -OR, -O(CH₂)_qOR or halogen, wherein q=2; R^v is independently specified in -R or halogen; R¹ and R° radical values are presented in the patent claim. The invention also refers to a pharmaceutical composition containing the above compounds.

EFFECT: preparing the compounds possessing the inhibitory activity on BTK, TEC, BMX, ITK, ErbB1, ErbB4 and/or JAK3 kinases.

17 cl, 25 dwg, 20 tbl, 286 ex