PYRAZOLE DERIVATIVES APPLIED AS PROTEIN KINASE INHIBITORS Russian patent published in 2008 - IPC C07D403/12 C07D401/14 C07D409/14 C07D403/14 C07D405/14 C07D413/14 C07D471/04 C07D487/04 C07D498/04 C07D491/04 C07D491/48 C07D491/52 C07D513/04 A61K31/506 A61K31/517 A61K31/519 A61K31/5377 A61P35/00 A61P25/28 A61P3/10 

Abstract RU 2340611 C2

FIELD: chemistry.

SUBSTANCE: claimed are novel pyrazole derivatives of formula II or its pharmaceutically acceptable salts, where C ring is selected from phenyl or pyridinyl ring and R2, R2', Rx and Ry are such as said in given description. C ring has ortho-substituent and is optionally substituted in non-ortho positions. R2 and R2' , optionally taken with their intermediate atoms, form condensed ring system, such s indazole ring, and Rx and Ry, optionally taken together with their intermediate atoms, form condensed ring system, such a quinazoline ring.

EFFECT: possibility to use compositions as inhibitors of protein kinases as inhibitors GSK-3 and other kinases and apply them for protein kinase-mediated diseases.

41 cl, 8 tbl, 423 ex

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RU 2 340 611 C2

Authors

Dehvis Robert

Bebbington Dehvid

Negtel Ronal'D

Vehnnamehjker Marion

Li Pehn

Forester Kornelija

Pirs Ehlbert

Kehj Dehvid

Dates

2008-12-10Published

2001-09-14Filed