AGENT IMPROVING ANTI-CANCER EFFECT AND CONTAINING LIPOSOMAL AGENT CONTAINING OXALIPLATIN, AND ANTI-CANCER AGENT CONTAINING LIPOSOMAL AGENT Russian patent published in 2013 - IPC A61K31/513 A61K31/4412 A61K31/53 A61K31/282 A61K9/127 A61K47/30 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to an anti-cancer agent and an agent improving anti-cancer effect and combined with a liposomal agent prepared by oxaliplatin encapsulation in a liposome, and a combined therapeutic agent containing tegafur, gimeracil and oteracil potassium. The liposome in the declared agents consists of dipalmitoyl phosphatidylcholine, cholesterol and 1,2-distearoyl-8n-glycero-3-phosphoethanolamine-n-[methoxy(polyethylene glycol)-2000; or hydrogenised soybean phosphatidylcholine, cholesterol and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-n-[methoxy(polyethylene glycol)- 2000; or dipalmitoyl phosphatidylcholine, cholesterol and 1,2-distearoyl- sn-glycero-3-phosphoethanolamine polyglycerol. The invention also refers to using the above liposomal agent for preparing the anti-cancer agent and for intensifying anti-cancer activity of the combined therapeutic agent containing tegafur, gimeracil and oteracil potassium. Also, the invention relates to a method of treating cancer by administering the liposomal agent comprising oxaliplatin encapsulated in a liposome, and the combination drug containing tegafur, gimeracil and oteracil potassium.

EFFECT: group of inventions enhances anti-cancer activity of the therapeutic agent without toxicity increase.

12 cl, 10 dwg, 11 ex