ACECLOFENAC-CONTAINING CONTROL RELEASE ORAL DOSAGE FORMS AND METHOD FOR PREPARING THEM Russian patent published in 2013 - IPC A61K31/216 A61K9/24 A61K47/30 A61K47/02 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to medicine and describes a prolonged release tablet of aceclofenac consisting of an immediate release layer containing aceclofenac, a water-soluble additive, a pH adjustor, a disintegrant, a filling agent and a lubricant, and a prolonged release layer containing aceclofenac, a release control polymer, a poorly soluble surfactant, a filling agent and a lubricant; the pH adjustor represents sodium hydrocarbonate; a release control polymer represents a mixture of hydroxypropylmethyl cellulose and carbomer; the mass ratio of mixed hydroxypropylmethyl cellulose and carbomer preferentially makes 10:1 to 20:1; sodium hydrocarbonate is contained in the amount of 0.25-1 wt % of total weight of the prolonged release tablet of aceclofenac; the water-soluble additive is contained in the amount of 0.75-3 wt % of total weight of the prolonged release tablet of aceclofenac.

EFFECT: invention provides the constant active drug concentration for the purpose of improving the therapeutic effect of the drug and facilitating the drug therapy for the patients with musculoskeletal pains, thereby improving the adherence to the drug therapy by the patients.

2 cl, 7 tbl, 12 ex