SUSTAINED-RELEASED ACECLOFENAC PREPARATION EXHIBITING FAST ANALGESIC AND ANTI-INFLAMMATORY ACTION POSSESSING OPTIMUM PHARMACOLOGICAL AND CLINICAL ACTION IF ADMINISTERED ONCE A DAY Russian patent published in 2015 - IPC A61K9/22 A61K9/20 A61K31/216 A61K47/38 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutics and represents a controlled-release aceclofenac preparation for oral administration once a day, exhibiting the fast analgesic and anti-inflammatory action, containing a fast-release layer containing aceclofenac, a solubiliser, a water-soluble additive, a disintegrating agent, a vehicle and a fast-acting additive, as well as a sustained-release layer containing aceclofenac, a solubiliser and a release control base consisting of mixture of hydroxypropyl methyl cellulose (HPMC) with a viscosity of 80,000 sP to 120,000 sP and carbomer taken in mass ratio 7:1 to 9:1.

EFFECT: invention provides a sequential and uniform dissolution rate and a controlled release of the active agent.

7 cl, 12 tbl, 11 dwg, 10 ex