METHOD OF TREATING LOCALLY ADVANCED VAGINAL CANCER Russian patent published in 2013 - IPC A61K31/282 A61K31/704 A61P35/00 A61H7/00 A61N5/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely oncology and concerns treating locally advanced vaginal cancer. For this purpose, the therapy is staged. The first stage involves the chemotherapeutic course that provides administering cisplatin 100 mg/m and doxorubicine 30 mg/m² intravenously drop-by-drop; the gamma-ray teletherapy covering a primary centre in a dose of 20 Gy is followed by two fractions 2.5 Gy of the intracavitary Co⁶⁰ therapy every 5 hours twice a week; in the middle of the 5-hour period, platidiam 5 mg dissolved in saline solution 1.0 ml is introduced into surface layers of the tumour which is exposed to ultrasound of frequency 880 kHz and intensity 0.4 Wt/cm² through the licensed dimexide gel tissue for 5 minutes; the therapy requires the gamma-ray teletherapy covering the lymphatic nodes alternated with 10-11 sessions of the intracavitary Co⁶⁰ therapy in total to reach a total dose of the primary centre exposure of 70-75 Gy, of the lymphatic nodes exposure of 40 Gy.

EFFECT: specified integrated therapy provides the effective treatment and prevention of the recurrences also ensured by using the chemotherapy combined with the ultrasonic exposure that promotes the deeper chemopreparation penetration into tumour tissues.

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