METHOD OF ADJUVANT THERAPY OF LOCALLY ADVANCED STOMACH CANCER Russian patent published in 2012 - IPC A61B17/00 A61N5/10 A61M3/02 A61M31/00 A61K31/196 A61K31/282 A61K31/495 A61K31/513 A61K31/704 A61K31/7004 A61K33/00 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, oncology, and may be used for treating the patients with stomach cancer T_3-4N_1-3M₀. Microirrigators are inserted in an abdominal cavity during a surgical intervention. An adjuvant treatment is applied 2-3 weeks later. It involves the endolymphatic introduction of methotrexate. It is followed by a two-week gamma-therapy in accelerated fractionation mode with single radiation dose (SRD) 1.2 Gy twice a day every 5 h. Eloxatine dissolved in ozonised 5% glucose is introduced drop-by-drop in microirrigators with underlying emission on 4th, 8th and 12th day from the beginning between fractionations. In the middle of an arranged pause, the radiation therapy involves single intravenous introduction of etoposide, leucovorin, 5-fluorouracil. The second stage involves the endolymphatic introduction of methotrexate, and 2 days later gamma-therapy is applied once more in the accelerated fractionation mode with SRD 1 Gy twice a day every 5 h with underlying on 32nd, 36th and 40th day from the beginning of treatment, eloxatine dissolved in ozonised 5% glucose is introduced drop-by-drop in microirrigators between fractionations.

EFFECT: method prolongs remission, terminates process generalisation, eliminates recurrences.

2 dwg, 1 ex