NAPHTHALENE CARBOXAMIDE DERIVATIVES AS PROTEIN KINASE AND HISTONE DEACETYLASE INHIBITORS, METHODS FOR PREPARING AND USING THEM Russian patent published in 2013 - IPC C07D215/22 C07D215/233 C07D239/88 C07D401/12 A61K31/438 A61K31/444 A61K31/517 A61P3/00 A61P9/00 A61P11/00 A61P25/00 A61P29/00 A61P35/00 A61P37/08 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to naphthalene carboxamide derivatives of general formula I which possess the properties of protein kinase or histone deacetylase inhibitors. The compounds can find application for preparing a drug for treating inflammatory diseases, autoimmune diseases, oncological disease, diseases of the nervous system and neurodegenerative diseases, allergies, asthma, cardiovascular diseases and metabolic diseases or disease related to hormonal diseases. In general formula I: , Z represents CH or N; each of the groups R¹, R² and R³ represents hydrogen, halogen, alkyl, alkoxy or trifluoromethyl; R⁴ represents or X represents a benzene ring or a pyridine ring; R⁵ represents one or more substitutes specified in a group consisting of hydrogen, halogen, alkyl, alkoxy or trifluoromethyl. The invention also refers to a method for preparing the above compounds, a pharmaceutical preparation and using them.

EFFECT: preparing the compounds which possess the properties of protein kinase or histone deacetylase inhibitors.

13 cl, 10 tbl, 6 dwg