QUINOLINIL-CONTAINING COMPOUND, ITS PHARMACEUTICAL COMPOSITION AND USE Russian patent published in 2023 - IPC C07D215/233 C07D401/12 C07D409/12 C07D417/12 A61K31/47 A61K31/4709 A61P1/16 A61P3/10 A61P9/00 A61P17/02 A61P25/28 A61P35/00 A61P37/02 

FIELD: pharmaceutical chemistry.

SUBSTANCE: group of inventions includes compounds of formula (I) or (II), specific compounds indicated in the claims, or their pharmaceutically acceptable salts, stereoisomers, their use and a method of treatment and inhibition based on them. Where in formulas (I) or (II) A represents or -NR₃R₄; X is hydrogen or halogen; Y is C_3-8cycloalkyl or C_6-20aryl substituted with halogen; Z is either -O- or -S-; L is linear -(CH₂)_n-, n is an integer from 3 to 10, where, optionally, one or more of -CH₂- is replaced by one or more -NR₅-, -(CO)- and -CR₅R₆ - and/or optionally one or more of -CH₂CH₂- may be replaced by -CH=CH-; R₁ is C_1-6 alkoxy or -(CO)NR₇R₈; R₂ is hydrogen, C_1-8alkylsulfanyl or -(CO)R₉; R₃ and R₄ are independently hydrogen or C_3-8 cycloalkyl; R₅ and R₆ independently represent hydrogen, C_1-8 alkyl or carboxyl; R₇ and R₈ are independently hydrogen; R₉ is C_1-4alkyl optionally substituted with one or more selected amino, hydroxyl, NHC(O)C_1-4alkyl groups; phenyl, C_1-4alkylene C_3-12heteroaryl, wherein heteroaryl contains one N atom and is optionally substituted with C_1-4alkyl, and C_1-4alkylene is substituted with a group selected from amino and NHC(O)C_1-4alkyl.

EFFECT: quinolinyl derivatives as VEGFR-2 and/or HDAC6 inhibitors.

16 cl, 3 tbl, 98 ex