PHENYLIMIDAZOLE COMPOUNDS Russian patent published in 2013 - IPC C07D233/64 C07D405/04 C07D409/04 A61K31/4164 A61K31/4178 A61P3/04 A61P3/06 A61P9/10 A61P43/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to organic chemistry, namely to new phenylimidazole derivatives of general formula , wherein R¹ represents a hydrogen atom, a phenyl lower-alkyl group or a pyridyl lower-alkyl group with a benzene ring and a pyridine ring are optionally substituted by 1 or 2 substitutes specified in a group consisting of halogen atoms, cyano group and halogen-substituted lower-alkyl groups; one or R² and R³ represents a hydrogen atom, and another one represents a lower alkoxy group; R⁴ represents a lower-alkyl group, a difurylglyoxal group, a thienyl group or a phenyl group optionally substituted by 1 or 2 substitutes specified in a group consisting of lower-alkyl groups, lower-alkoxy groups, halogen atoms, a carboxyl group, lower alkoxycarbonyl groups, and halogen-substituted lower-alkyl groups; R⁵ and R⁶ are identical or different, and represent a hydrogen atom or a lower alkyl group; R⁷ and R⁸ are identical or different, and represent a hydrogen atom or a lower alkoxy group; provided R¹ represents an unsubstituted phenyl lower-alkyl group, R² represents a lower alkoxy group, R³ represents a hydrogen atom, R⁴ represents an unsubstituted phenyl group or a phenyl group containing 1 or 2 halogen-substituted lower-alkyl groups, and R⁵ represents a hydrogen atom, then R⁶ is other than a hydrogen atom. Also, the invention refers to an LPL activator, an agent for preventing or treating hyperlipidaemia, an agent for treating arteriosclerosis, and an agent for treating obesity on the basis of the compound of formula (1).

EFFECT: there are prepared new phenylimidazole derivatives effective for LPL activation.

23 cl, 10 tbl, 7 ex