N-((HET)ARYLMETHYL)-HETEROARYL-CARBOXAMIDE COMPOUNDS AS PLASMA KALLIKREIN INHIBITORS Russian patent published in 2024 - IPC C07D401/14 C07D231/14 C07D401/06 C07D401/10 C07D403/10 C07D409/14 C07D413/14 A61K31/415 A61K31/454 A61K31/4709 A61K31/497 A61K31/506 A61P43/00 

Abstract RU 2821520 C2

FIELD: medicine; pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical compositions for treating diseases or conditions associated with plasma kallikrein activity. Disclosed is a pharmaceutical composition for treating a disease or condition associated with plasma kallikrein activity, containing: (i) a pharmaceutically acceptable carrier, diluent or excipient and (ii) a compound of formula (I), wherein R5, R6, R7, A, B, W, X, Y and Z are as defined in the claims, or a pharmaceutically acceptable compound thereof salt or solvate. Also disclosed are a compound of formula (I), its use in a method of treating a disease or condition which is associated with plasma kallikrein activity, a corresponding method of treating, as well as a pharmaceutical composition having the ability to inhibit plasma kallikrein activity.

EFFECT: content of low-molecular compounds in the pharmaceutical composition, which selectively inhibit plasma kallikrein, improves oral accessibility.

24 cl, 15 tbl, 140 ex

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RU 2 821 520 C2

Authors

Dejvi, Rebekka Luiz

Edvards, Khannakh Dzhoj

Evans, Devid Majkl

Khodgson, Sajmon Tinbi

Dates

2024-06-25Published

2015-11-26Filed