FIELD: medicine; pharmaceutics.
SUBSTANCE: invention relates to pharmaceutical compositions for treating diseases or conditions associated with plasma kallikrein activity. Disclosed is a pharmaceutical composition for treating a disease or condition associated with plasma kallikrein activity, containing: (i) a pharmaceutically acceptable carrier, diluent or excipient and (ii) a compound of formula (I), wherein R5, R6, R7, A, B, W, X, Y and Z are as defined in the claims, or a pharmaceutically acceptable compound thereof salt or solvate. Also disclosed are a compound of formula (I), its use in a method of treating a disease or condition which is associated with plasma kallikrein activity, a corresponding method of treating, as well as a pharmaceutical composition having the ability to inhibit plasma kallikrein activity.
EFFECT: content of low-molecular compounds in the pharmaceutical composition, which selectively inhibit plasma kallikrein, improves oral accessibility.
24 cl, 15 tbl, 140 ex
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