NOVEL VANILLOID RECEPTOR LIGANDS AND USE THEREOF IN PRODUCING MEDICINAL AGENTS Russian patent published in 2013 - IPC C07D401/12 C07D417/12 C07D231/56 C07D241/42 C07D249/18 C07D265/36 C07D319/18 A61K31/423 A61K31/4184 A61K31/538 A61K31/498 A61K31/4192 A61K31/44 A61K31/47 A61P29/00 A61P25/28 A61P11/00 A61P13/00 A61P1/00 

FIELD: chemistry.

SUBSTANCE: invention relates organic chemistry and specifically to novel pyridine amide derivatives of general formula I where n equals 1; R¹ and R² together denote a residue selected from a group consisting of -CH=N-NH- and -CH=CH-N=CH-, which is bonded in any desirable direction to the parent structure or R² and R³ together denote a residue selected from a group consisting of -CH=N-NH-; -CR²⁸=N-NH-; -S-C(=S)-NH-; -S-CR²⁹=N-; -N=CR³⁰-O-; -N=CH-NH-; -N=N-NH-; -O-CH₂-O-; -CH₂-CH₂-CH₂-NH, -O-CH₂-CH₂-O-; -N=CH-CH=N-; -CH=CH-CH=N-, which is bonded in any desirable direction to the parent structure, or R³ and R⁴ together denote a -CH=N-NH- residue, which is bonded in any desirable direction to the parent structure, or R⁴ and R⁵ together denote a -CH=N-NH- residue, which is bonded in any desirable direction to the parent structure, and the rest of the residues R¹, R², R³, R⁴ and R⁵, mutually independently, in each case denote H; where R²⁸ denotes F; Cl; Br or I; R²⁹ and R³⁰, mutually independently, in each case denote -NH-C(=O)-R³¹; -NH₂; -NH-S(=O)₂-R³²; -NH-C(=O)-O-R³³; -S-R³⁴; where R³¹, R³², R³³ and R³⁴, mutually independently, in each case denote a straight or branched, saturated, unsubstituted aliphatic C_1-10 residue; R⁶ denotes H or denotes a straight or branched, saturated, unsubstituted aliphatic C_1-10 residue; R⁷ denotes hydrogen or -OH; R denotes -CF₃; or denotes an unsubstituted tert-butyl residue; T denotes C-R³⁵ and U denotes C-R³⁶, V denotes N and W denotes C-R³⁸; where R³⁵ and R³⁶ denote H; where R³⁸ denotes -NR⁴⁰R⁴¹; -OR⁴² or -SR⁴³; where R⁴⁰, R⁴¹, R⁴² and R⁴³, mutually independently, in each case denote a straight or branched, saturated, unsubstituted aliphatic C_1-10 residue; or denote a saturated, unsubstituted 3-, 4-, 5-, 6-, 7-, 8- or 9-member cycloaliphatic residue, or where R⁴⁰ and R⁴¹ in each case together with a nitrogen atom as a ring member which binds them together, form a saturated 6-member heterocycloaliphatic residue, optionally substituted with one R⁵⁷ residue, where R⁵⁷ denotes a straight or branched, saturated, unsubstituted aliphatic C_1-10 residue; in each case in form of corresponding physiologically acceptable salts. The invention also relates to a method of producing a compound of formula I, a medicinal agent based on the compound of formula I and use of the compound of formula I.

EFFECT: obtaining novel amide derivatives of pyridine, useful in treating vanilloid receptor 1 mediated diseases.

25 cl, 1 tbl, 18 ex