NEW BICYCLIC COMPOUNDS AS DUAL INHIBITORS OF ATX/CA Russian patent published in 2020 - IPC C07D471/04 C07D487/04 A61K31/407 A61K31/437 A61P27/02 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I)

(I)

and pharmaceutically acceptable salts thereof. In formula (I): R¹ represents substituted phenyl-C_1-6-alkyl substituted by phenoxy-C_1-6-alkyl, substituted phenyl-C_2-6-alkenyl, substituted quinolinyl, substituted quinolinyl-C_1-6-alkyl, substituted quinolinyl-C_1-6-alkenyl, substituted quinolinyl-C_1-6-alkynyl, substituted pyridinyl, substituted pyridinyl-C_1-6-alkyl, where substituted phenyl-C_1-6-alkyl, substituted phenoxy-C_1-6-alkyl, substituted phenyl-C_2-6-alkenyl, substituted quinolinyl, substituted quinolinyl-C_1-6-alkyl, substituted quinolinyl-C_1-6-alkenyl, substituted quinolinyl-C_1-6-alkynyl, substituted pyridinyl, substituted pyridinyl-C_1-6-alkyl, substituted by R³, R⁴ and R⁵; Y is -OC(O)- or -C(O)-; W is -C(O)-, -S(O)₂-; R² denotes substituted phenyl, substituted pyridinyl, where substituted phenyl, substituted pyridinyl is substituted by R⁶, R⁷ and R⁸; R³ represents halogen, cyano, C_1-6-alkyl, halogen-C_1-6-alkoxy, halogen-C_1-6-alkyl, C_3-8-cycloalkyl, C_3-8-cycloalkyl-C_1-6-alkyl, C_1-6-alkilkarbonilamino, C_1-6-alkiltetrazolyl, C_1-6-alkiltetrazolyl-C_1-6-alkyl or (heterocycloalkyl, containing 1 heteroatom selected from N and O)-C_1-6-alkoxy; R⁴ and R⁵ are independently selected from H, halogen, cyano, C_1-6-alkyl, halogen-C_1-6-alkoxy, halogen-C_1-6-alkyl, C_3-8-cycloalkyl, C_3-8-cycloalkyl-C_1-6-alkyl, C_1-6-alkylcarbonylamino, C_1-6-alkiltetrazolyl_, C_1-6-alkiltetrazolyl-C_1-6-alkyl and (heterocycloalkyl containing one heteroatom selected from N and O)-C_1-6-alkoxy; R⁶ is aminosulphonyl; R⁷ and R⁸ are independently selected from H, halogen; m, n, p and q are independently selected from 1 or 2. Also disclosed are a pharmaceutical composition, use of the compound and a method of inhibiting autotaxin and carbonic anhydrase.

EFFECT: disclosed compounds have the effect of a double inhibitor of autotaxin (ATX) / carbonic anhydrase and can be used for treating or preventing diseases, disorders or conditions, which are associated with autotaxin activity and/or biological activity of lysophosphatidic acid (LPA).

31 cl, 7 ex