FIELD: biotechnologies.
SUBSTANCE: invention proposes variable domains of heavy (VH) and light (VL) chains of murine antibody against tumour necrosis factor alpha (TNF-α) of a human being, as well as antigen-binding fragment Fab, which are selectively bound to TNF-α of the human being and neutralise it.
EFFECT: invention can be further used in development of medicines for therapy of TNF-α-mediated diseases and for diagnostics of such diseases.
3 cl, 5 tbl, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| VARIABLE DOMAINS OF LIGHT AND HEAVY CHAIN OF THE MOUSE MONOCLONAL ANTIBODY AGAINST INTERFERON ALPHA (IFN-α) HUMAN ANTIGEN BINDING FRAGMENTS (FAb) AGAINST HUMAN IFN-α COMPRISING SAID DOMAINS | 2018 |
|
RU2694672C1 |
| VARIABLE DOMAINS OF A LIGHT AND HEAVY CHAIN OF A HUMAN CATHEGERIN-17 MOUSE MONOCLONAL ANTIBODY, AN ANTIGEN-BINDING FRAGMENT (FAB) AGAINST HUMAN CADHERIN-17, CONTAINING SAID DOMAINS | 2018 |
|
RU2703949C1 |
| HUMANISED ANTIBODY TO TNF-α, ITS ANTIGEN-BINDING FRAGMENT (Fab) AND THEIR APPLICATION | 2011 |
|
RU2556815C2 |
| HUMANISED ANTIGEN-BINDING FRAGMENTS (Fab) AGAINST RABIES VIRUS, ISOLATED DNA FRAGMENT, CODING Fab AGAINST RABIES VIRUS, YEAST CELL, TRANSFORMED BY DNA FRAGMENT, AND METHOD OF OBTAINING Fab AGAINST RABIES VIRUS WITH APPLICATION OF YEASTS | 2010 |
|
RU2440412C2 |
| ANTIBODIES AGAINST TNF-α AND USE THEREOF | 2010 |
|
RU2595379C2 |
| ANTIGEN BINDING SECTION (FAB), INCLUDING HUMANIZED FAB, AGAINST BOTULINICAL NEUROTOXIN C (VERSIONS), METHOD TO OBTAIN FAB USING YEAST, METHOD AND SET FOR BOTULINICAL NEUROTOXIN C DETECTION | 2016 |
|
RU2623157C1 |
| HUMANISED ANTIBODIES AGAINST TNFα | 2012 |
|
RU2549700C1 |
| MURINE MONOCLONAL ANTIBODIES BOUND WITH ANTIGEN F1 OF Yersinia pestis, METHOD FOR PRODUCING THEREOF WITH USING YEAST, METHOD AND KIT FOR Yersinia pestis DETECTION | 2009 |
|
RU2420588C2 |
| HUMANISED ANTIBODIES AND Fab BOUND WITH ANTIGEN F1 OF Yersinia pestis, AND METHOD FOR PRODUCING THEREOF WITH USING YEAST | 2009 |
|
RU2420587C2 |
| ANTIBODIES RAISED AGAINST α-INTERFERON | 2002 |
|
RU2314317C2 |
