FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutical industry, and represents a local skin composition which is an oil-in-water-in-oil emulsion containing a water phase with a dispersed lipophilic phase containing calcipotriol or monohydrate in the dissolved form; a non-ionic surfactant specified in a group consisting of polyethylene glycol glycerides and C6-20 fatty acids, polyoxyethylene C8-20 alkyl ethers or polysorbates and a lower alkanol as a co-solvent; the above water phase is dispersed in a pharmaceutically acceptable anhydrous lipophilic carrier or base.
EFFECT: invention provides the effective dissolution of calcipotriol with the lower content of a lower alcohol, as well as the good penetration of calcipotriol into the viable skin layers, higher biological activity and less skin irritation.
26 cl, 5 ex, 7 tbl, 6 dwg
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