ICOTINIB-CONTAINING TOPICAL SKIN PHARMACEUTICAL COMPOSITIONS AND USE THEREOF Russian patent published in 2019 - IPC A61K9/06 A61K31/517 A61K47/02 A61K47/06 A61K47/32 A61K47/44 A61P17/06 

FIELD: chemistry; pharmaceutics.

SUBSTANCE: group of inventions relates to the chemical-pharmaceutical industry and is a topically active cutaneous pharmaceutical composition for treating non-malignant skin hyperplasia, comprising an active ingredient, capable of inhibiting tyrosine kinase, and an adjuvant suitable for a local action preparation, characterized in that the active ingredient includes icotinib in form of a free base, icotinib hydrochloride, icotinib maleate or icotinib phosphate; wherein the excipient includes a dispersion medium, an emulsifier and/or one or more pharmaceutically acceptable excipients of the topical preparation. Inventions also include a method of treating a mammalian disease associated with non-malignant skin hyperplasia.

EFFECT: group of inventions enables to obtain topical preparations with minimal skin irritation without adverse reactions such as itching, burning sensation, tingling, dry skin, erythema and eruption, without para-hormone-related side effects such as skin atrophy, pigmentation or hypopigmentation with prolonged use, as well as without associated dermatological symptoms after drug withdrawal.

43 cl, 9 tbl, 59 ex