FIELD: chemistry.
SUBSTANCE: invention relates to novel substituted 6-(1-piperazinyl)-pyridazines of formula 
, where R1 is chlorine, trifluoromethyl or cyano; R2 is phenyl or phenyl substituted with a halogen; R*1 is hydrogen, C1-4-alkyl or pyridinylmethyl; X is -O-, -NH-, -CH2-, -CH(OH)-, -SO2-, -CO-, -NH-CH2-, -O-CH2-, 1,2-ethendiyl or ethyndiyl; or a pharmaceutically acceptable addition salt or solvate thereof as well as pharmaceutical compositions containing said novel compound as an active ingredient.
EFFECT: improved properties of derivatives.
8 cl, 4 tbl, 6 ex
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