PYRROLOCHINOLINE DERIVATIVES AS 5-HT ANTAGONISTS, METHODS FOR PRODUCTION THEREOF AND USE Russian patent published in 2019 - IPC C07D471/04 A61K31/4745 A61K31/496 A61K31/5377 A61K31/551 A61P1/00 A61P3/10 A61P25/06 A61P25/08 A61P25/18 A61P25/20 A61P25/28 A61P29/00 A61P43/00 

FIELD: organic chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to a pyrrolochinoline derivative of formula (XIV) or a stereoisomer or pharmacologically acceptable salt or hydrate thereof, where R₁, R₂ independently represent hydrogen, alkoxy (C₁-C₃) a group or an independently selected from cyano, nitro, amino; T is CO, CH₂, SO₂; Ar is aryl (6-member), optionally substituted with one or two substitutes selected from alkyl(C₁-C₃) groups, alkyl(C₁-C₃) a group substituted with three halogen atoms, alkoxy(C₁-C₃) a group, halogen, cyano and amino; unsubstituted biaryl (10-member); heteroaryl (5-member) containing 1 S atom and optionally substituted with one halogen atom; heteroaryl (9-10-membered) containing 1 heteroatom, selected from a group consisting of N and S, and optionally substituted with one or two substitutes selected from alkyl (C₁-C₃) a group and a halogen; R₃ is a substitute, selected from a group of cyclic or linear, substituted or unsubstituted amines, consisting of structures (XV)–(XVIII), where A is NH, O, CH₂, NR₅; BR₄ is NH, O; R₅ is alkyl (C₁-C₃) a group or benzyl; R₆ is alkyl (C₁-C₃) a group; n is selected from 0, 1, 2; m is selected from 1, 2; l is equal to 1. Invention also relates to specific derivatives of pyrroloquinoline, a pharmaceutical composition based on said compound and use thereof, an intermediate compound of formula (XIX) and a method of producing an intermediate compound.

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EFFECT: technical result is obtaining novel pyrroloquinoline derivatives, useful in treating diseases caused by disturbed signal transmission through 5-HT₆-receptors.

14 cl, 7 dwg, 6 tbl