FIELD: organic chemistry.
SUBSTANCE: invention relates to organic chemistry and specifically to a pyrrolochinoline derivative of formula (XIV) or a stereoisomer or pharmacologically acceptable salt or hydrate thereof, where R1, R2 independently represent hydrogen, alkoxy (C1-C3) a group or an independently selected from cyano, nitro, amino; T is CO, CH2, SO2; Ar is aryl (6-member), optionally substituted with one or two substitutes selected from alkyl(C1-C3) groups, alkyl(C1-C3) a group substituted with three halogen atoms, alkoxy(C1-C3) a group, halogen, cyano and amino; unsubstituted biaryl (10-member); heteroaryl (5-member) containing 1 S atom and optionally substituted with one halogen atom; heteroaryl (9-10-membered) containing 1 heteroatom, selected from a group consisting of N and S, and optionally substituted with one or two substitutes selected from alkyl (C1-C3) a group and a halogen; R3 is a substitute, selected from a group of cyclic or linear, substituted or unsubstituted amines, consisting of structures (XV)–(XVIII), where A is NH, O, CH2, NR5; BR4 is NH, O; R5 is alkyl (C1-C3) a group or benzyl; R6 is alkyl (C1-C3) a group; n is selected from 0, 1, 2; m is selected from 1, 2; l is equal to 1. Invention also relates to specific derivatives of pyrroloquinoline, a pharmaceutical composition based on said compound and use thereof, an intermediate compound of formula (XIX) and a method of producing an intermediate compound.
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EFFECT: technical result is obtaining novel pyrroloquinoline derivatives, useful in treating diseases caused by disturbed signal transmission through 5-HT6-receptors.
14 cl, 7 dwg, 6 tbl
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Authors
Dates
2019-05-20—Published
2013-07-25—Filed