METHOD OF ANTIMICROBIAL COATING FORMATION Russian patent published in 2014 - IPC A61F2/30 A61K33/06 A61P31/04 C23C4/12 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to maxillofacial surgery and traumatology and can be applied for formation of antimicrobial coating in manufacturing titanium-based intra-tissue endoprostheses. For this purpose preliminary preparation of silver-containing solution, preliminary preparation of implant surface and coating formation are carried out. In the process of preparation of silver-containing solution first hydroxyapatite powder is placed into 0.04% solution of AgNO₃. After that, powder is kept in air at room temperature for the time necessary for qualitative soaking of hydroxyapatite particles with AgNO₃ solution. Then, sediment is filtered and washed with hot water, and dried at 200°-300°C for 4-6 hours and annealed at 600°-700°C for 2-3 hours. Preliminary preparation of implant surface is performed by jet processing of surface with electrocorundum powder under pressure. Formation of coating is carried out by plasma sputtering of first titanium sublayer and then silver-containing hydroxyapatite powder. Plasma sputtering of titanium sublayer is performed at voltage 35 V, current intensity 450 A, distance of sputtering 100 mm and titanium powder dispersion 100-120 mcm, consumption of argon being 55-60 l/min. Plasma sputtering of silver-containing hydroxyapatite powder is performed at current intensity 450 A, voltage 36 A, distance 80 and 120 mm, dispersion 70-75 mcm and argon consumption 65-70 l/min.

EFFECT: method ensures obtaining implant coating, contributing to fast and reliable osteointegration of the implant due to formation of developed surface morphology and creation of antimicrobial effect in tissues adjacent to endoprosthesis.

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