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2 504 548

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IPC

C07D501/36(2006-01-01)

A61K31/546(2006-01-01)

A61P31/04(2006-01-01)

(21) (22)

Application

2012141612/04, 2012-09-28

(24)

Start date

2012-09-28

(22)

Actual filing date

2012-09-28

(45)

Published

2014-01-20

(72)

Inventor

Novikova Galina VladimirovnaStaloverova Natal'Ja Anatol'Evna

(73)

Holder

Federal'Noe Gosudarstvennoe Avtonomnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Federal'Nyj Universitet"

DERIVATIVE OF β-LACTAM CEFTRIAXONE ANTIBIOTIC Russian patent published in 2014 - IPC C07D501/36 A61K31/546 A61P31/04

Abstract RU 2504548 C1

FIELD: biotechnologies.

SUBSTANCE: invention refers to a new derivative of β-lactam ceftriaxone antibiotic, which is presented with general formula (I), containing group R₁=3-[[(2-methyl-6-oxide-5-oxo-2,5-dihydro-1,2,4-triazine-3-il)sulphanyl]methyl] (a), where R₂=sodium, R₃=2-amino-3-mercaptopropionate ion -HOOC-CH(NH₂)-CH₂-S^-. Compound is synthesised with interaction of β-lactam ceftriaxone antibiotic with amino acid with cysteine.

EFFECT: derivative of β-lactam ceftriaxone antibiotic, which shows antibacterial properties in relation to bacteria Staphylococcus aureus 25923 and Escherichia coli 25922.

2 cl, 1 tbl

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RU 2 504 548 C1

Authors

Novikova Galina Vladimirovna

Staloverova Natal'Ja Anatol'Evna

Dates

2014-01-20—Published

2012-09-28—Filed