DERIVATIVE OF β-LACTAM CEFTRIAXONE ANTIBIOTIC Russian patent published in 2014 - IPC C07D501/36 A61K31/546 A61P31/04 

Abstract RU 2504548 C1

FIELD: biotechnologies.

SUBSTANCE: invention refers to a new derivative of β-lactam ceftriaxone antibiotic, which is presented with general formula (I), containing group R1=3-[[(2-methyl-6-oxide-5-oxo-2,5-dihydro-1,2,4-triazine-3-il)sulphanyl]methyl] (a), where R2=sodium, R3=2-amino-3-mercaptopropionate ion -HOOC-CH(NH2)-CH2-S-. Compound is synthesised with interaction of β-lactam ceftriaxone antibiotic with amino acid with cysteine.

EFFECT: derivative of β-lactam ceftriaxone antibiotic, which shows antibacterial properties in relation to bacteria Staphylococcus aureus 25923 and Escherichia coli 25922.

2 cl, 1 tbl

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Authors

Novikova Galina Vladimirovna

Staloverova Natal'Ja Anatol'Evna

Dates

2014-01-20Published

2012-09-28Filed