TAZOBACTAM ARGININE ANTIBIOTIC COMPOSITIONS Russian patent published in 2018 - IPC A61K31/546 A61K31/545 A61K31/43 A61K31/198 A61P31/04 

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions relates to the chemical-pharmaceutical industry and is a pharmaceutical composition for treating a bacterial infection in a mammal, comprising crystalline tazobactam arginine, which is characterised by an X-ray powder diffraction pattern having characteristic peaks, expressed in 2-theta degrees at angles about 4.8 ° ± 0.3 °, about 8.9 ° ± 0.3 °, about 11.3 ° ± 0.3 °, about 14.9 ° ± 0.3 °, about 18.0 ° ± 0.3 °, about 19.4 ° ± 0.3 °, about 21.2 ° ± 0.3 °, about 22.8 ° ± 0.3 ° and about 24.3 ° ± 0.3 °, and 5-amino-4-{[(2-aminoethyl)carbamoyl]amino}-2-{[(6R,7R)-7-({(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetyl}amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-1-methyl-1H-pyrazole monosulphate. Invention also provides a method for preparing the pharmaceutical composition described above and a method of treating bacterial infections in a mammal using the pharmaceutical composition.

EFFECT: group of inventions makes it possible to obtain a dosage form in which the degree of decomposition of ceftolozane and the amount of by-products decreases.

29 cl, 5 dwg, 4 tbl, 3 ex