METHOD OF OBTAINING ALKYL ESTER OF BENDAMUSTINE, BENDAMUSTINE, AND ITS DERIVATIVES Russian patent published in 2014 - IPC C07D235/16 C07C227/16 C07C227/18 

FIELD: chemistry.

SUBSTANCE: invention relates to method of obtaining compound, described by formula (I) or its salt, where X stands for halogen residue, and R¹ and R² together stand for residue, described by formula (II), where R⁴ and R⁵ independently on each other represent alkyl residue and n represents number in the range 0-12. In accordance with claimed method compound of formula (III) is introduced into reaction with mixture, containing compound (i), selected from group, consisting of compound of formula (IV), where R⁶ represents H or alkyl residue, and R⁷ and R⁸ independently on each other represent alkyl residue, and compound of formula (V) where R⁹ and R¹⁰ independently on each other represent alkyl residue, and compound (ii), which is described by formula (VI). R¹ and R² in compound of formula (III) and X in compound of formula (VI) are determined above for compound of formula (I). Invention also relates to method of obtaining respective acids by hydrolysis of ester group in compound of formula (I).

EFFECT: claimed methods make it possible to obtain desired compounds with reproducible high outputs and can be applied in synthesis of bendamustine derivatives, used in chemical therapy of various cancer diseases.

14 cl, 3 ex