FIELD: chemistry.
SUBSTANCE: invention relates to method of obtaining compound, described by formula (I) or its salt, where X stands for halogen residue, and R1 and R2 together stand for residue, described by formula
(II), where R4 and R5 independently on each other represent alkyl residue and n represents number in the range 0-12. In accordance with claimed method compound of formula
(III) is introduced into reaction with mixture, containing compound (i), selected from group, consisting of compound of formula
(IV), where R6 represents H or alkyl residue, and R7 and R8 independently on each other represent alkyl residue, and compound of formula
(V) where R9 and R10 independently on each other represent alkyl residue, and compound (ii), which is described by formula
(VI). R1 and R2 in compound of formula (III) and X in compound of formula (VI) are determined above for compound of formula (I). Invention also relates to method of obtaining respective acids by hydrolysis of ester group in compound of formula (I).
EFFECT: claimed methods make it possible to obtain desired compounds with reproducible high outputs and can be applied in synthesis of bendamustine derivatives, used in chemical therapy of various cancer diseases.
14 cl, 3 ex
Authors
Dates
2014-01-27—Published
2011-12-21—Filed