BENDAMUSTINE DERIVATIVES, RELATED COMPOUNDS AND THEIR MEDICAL APPLICATION FOR TREATING CANCER Russian patent published in 2019 - IPC C07D235/12 A61K31/4184 A61P35/00 

Abstract RU 2695383 C2

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to a heterocyclic compound of formula IX or a pharmaceutically acceptable salt thereof, where R1 is C1-C6 alkyl; R2 is C1-C6 alkanediyl; Y1 and Y2 represent oxygen, wherein bis(2-chloroethyl)amino group is bonded at position 6 of benzimidazole ring structure. Invention also relates to a compound of formula VIII, an intermediate compound of formula VII, methods of producing said compounds and a pharmaceutical composition based on compounds of formulas IX and/or VIII.

EFFECT: technical result is obtaining new compounds having antiproliferative and/or cytotoxic activity.

16 cl, 8 ex

Similar patents RU2695383C2

Title Year Author Number
METHOD OF PRODUCING CANDESARTAN 2005
  • Vang Japing
  • Li Jongang
  • Di Julin
  • Zheng Guodzhun
  • Li Ji
  • Kekher Shtefan
RU2407741C2
NOVEL PHENYLPYRAZINONES AS KINASE INHIBITORS 2009
  • D'Judni Nolan Dzhejms
  • Lou Jan'
  • Shogren Ehrik Brajan
  • Sot Majkl
  • Suini Zakhari Kevin
RU2507202C2
USING EP4 RECEPTOR ANTAGONISTS IN TREATING IL-23-MEDIATED DISEASES 2011
  • Kanazava Kijosi
  • Nonomura Kadzukhiko
  • Okumura Takako
  • Koidzumi Siniti
RU2571816C2
DERIVATIVES OF BENZIMIDAZOLE AND METHOD PRODUCTION THEREOF 1987
  • Tomas Ber'E Al'Minger[Se]
  • Rol'F Aksel' Bergman[Se]
  • Khans Bungord[Dk]
  • Per Lennart Lindberg[Se]
  • Gunnel Ehlizabet Sunden[Se]
RU2062778C1
INHIBITORS OF METALLOPROTEINASES, THEIR USING AND PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF 2002
  • Ehriksson Anders
  • Lepiste Matti
  • Lundkvist Mikaehl'
  • Munk Af Rozenskel'D Magnus
  • Zlatojdskij Pavol
RU2293729C2
DERIVATIVES OF THIOPHENE 2003
  • Ehndrjus Klarens U. Tretij
  • Chijung M'Jui
  • Dehjvis-Uord Ronda Dzh.
  • Druri Dejvid Kharol'D
  • Ehmmitt Kajl Allen
  • Khabbard Robert Dejl
  • Kunts Kevin U.
  • Linn Dzhejms Ehndrju
  • Muk Robert Ehntoni
  • Smit Gehri Kejt
  • Vil Dzhejms Marvin
RU2296758C2
PRODUCT COMPRISING AT LEAST ONE SUBSTANCE INHIBITING ACTIVITY OF NO-SYNTHASE IN COMBINATION WITH AT LEAST ONE SUBSTANCE INHIBITING ACTIVITY OF PHOSPHOLIPASE A 2000
  • Oge Mishel'
  • Shabrie De Lasson'Er P'Er-Eht'Enn
RU2256465C2
IMIDAZOLE DERIVATIVES, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF 1991
  • Mishel' Fortehn[Fr]
  • Daniel' Freshe[Fr]
  • Zhil' Amon[Fr]
  • Simon Zhukej[Fr]
  • Zhan-Pol' Vever[Fr]
RU2099342C1
SERINE/THREONINE KINASE INHIBITORS 2013
  • Blejk Dzhejms F.
  • Chikarelli Mark Jozef
  • Gerri Rustam Ferdinand
  • Gaudino Dzhon
  • Grina Dzhonas
  • Moreno Devid A.
  • Mor Peter Dzh.
  • Ren Li
  • Shvarts Dzhejkob
  • Chen Khuejfen
  • Robardzh Kirk
  • Chzhou Ajkhe
RU2650501C2
METHOD OF OBTAINING ALKYL ESTER OF BENDAMUSTINE, BENDAMUSTINE, AND ITS DERIVATIVES 2011
  • Gro Kaj
  • Rauter Khol'Ger
  • Born Dirk
RU2505533C2

RU 2 695 383 C2

Authors

Shikkaneder Khelmut

Shikkaneder Kristian

Bushauer Armin

Bernkhardt Gyunter

Khuber Shtefan

Limmert Mikhael

Lubbe Matias

Khofmajer Garald

Dates

2019-07-23Published

2013-06-14Filed