FIELD: biotechnologies.
SUBSTANCE: invention relates to method for obtaining of RTX-toxins Apxl or ApxIII by culturing of Actinobacillus pleuropneumoniae bacteria in liquid culture media. Characterised method consists in the following: during exponential growth phase of bacteria and production of RTX-toxins air passes through the medium, carbon dioxide content in air is above normal atmospheric level and is up to 10 % vol.
EFFECT: invention allows increasing Apxl or ApxIII toxins output, this may be used during vaccines production.
7 cl, 4 tbl
| Title |
Year |
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Number |
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