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2 507 598

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IPC

G09B23/28(2006-01-01)

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Application

2012124210/14, 2012-06-09

(24)

Start date

2012-06-09

(22)

Actual filing date

2012-06-09

(45)

Published

2014-02-20

(72)

Inventor

Pokrovskij Mikhail VladimirovichLazarenko Viktor Anatol'EvichKolesnik Inga MikhajlovnaEfremenkova Dar'Ja Afonas'EvnaPokrovskaja Tat'Jana Grigor'EvnaDolzhikov Aleksandr Anatol'EvichKhodov Sergej VladimirovichGudyrev Oleg SergeevichMolchanova Ol'Ga ViktorovnaKochkarov Vladimir IskhakovichZhernakova Nina IvanovnaDolzhikova Irina NikolaevnaDanilenko Ljudmila MikhajlovnaPapunashvili Mikhail MerabovichGureev Vladimir VladimirovichAlekhin Sergej AleksandrovichTrofimov Konstantin SergeevichJakushev Vladimir Vladimirovich

(73)

Holder

Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Meditsinskij Universitet" Ministerstva Zdravookhranenija I Sotsial'Nogo Razvitija Rossijskoj Federatsii

METHOD FOR PHARMACOLOGICAL STIMULATION OF PEDICLE SKIN FLAP SURVIVAL WITH NICORANDYL Russian patent published in 2014 - IPC G09B23/28

Abstract RU 2507598 C1

FIELD: medicine.

SUBSTANCE: pedicle skin flap survival is corrected in laboratory animals is corrected by modelling a flap on the second experimental day. On the first and fourth day of the experiment, nicorandyl is introduced intraperitoneally in a daily dose of 1.3 mg/kg in two stages.

EFFECT: higher skin flap survival in the reduced blood circulation environment ensured by opening the ATP-dependent potassium channels and providing the nitrate-like effect of nicorandyl in the specific experimental environment.

1 ex, 1 tbl

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RU 2 507 598 C1

Authors

Pokrovskij Mikhail Vladimirovich

Lazarenko Viktor Anatol'Evich

Kolesnik Inga Mikhajlovna

Efremenkova Dar'Ja Afonas'Evna

Pokrovskaja Tat'Jana Grigor'Evna

Dolzhikov Aleksandr Anatol'Evich

Khodov Sergej Vladimirovich

Gudyrev Oleg Sergeevich

Molchanova Ol'Ga Viktorovna

Kochkarov Vladimir Iskhakovich

Zhernakova Nina Ivanovna

Dolzhikova Irina Nikolaevna

Danilenko Ljudmila Mikhajlovna

Papunashvili Mikhail Merabovich

Gureev Vladimir Vladimirovich

Alekhin Sergej Aleksandrovich

Trofimov Konstantin Sergeevich

Jakushev Vladimir Vladimirovich

Dates

2014-02-20—Published

2012-06-09—Filed