FIELD: chemistry.
SUBSTANCE: present invention relates to indole benzylamino compound of formula I
and pharmaceutically acceptable salts thereof. The invention also relates to use of the compound to treat a patient in such a physiological state or susceptible to such a physiological state which needs improvement by inhibiting tryptase and involves administering a therapeutically effective amount of the compound to the patient. The present invention also relates to a pharmaceutical composition containing a pharmaceutically effective amount of the compound of formula I for treating the physiological state by inhibiting tryptase.
EFFECT: novel compound which can be used as a tryptase inhibitor is obtained and described.
17 cl, 13 ex, 2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| TREATMENT OF DERMATOLOGICAL ALLERGIC STATES | 2011 |
|
RU2521357C2 |
| SYNTHESIS OF TERTBUTYL ESTER OF (4-FLUORO-3-PYPERIDIN-4-YL-BENZYL)-CARBAMIC ACID AND ITS INTERMEDIATE PRODUCTS | 2010 |
|
RU2543483C2 |
| MODULATORS OF NUCLEAR RECEPTORS | 2016 |
|
RU2715897C2 |
| [4-(5-AMINOMETHYL-2-FLOUROPHENYL)-PYPERIDIN-1-YL]-(4-BROMINE-3-PROPOXYTHIOPHENE-2-YL)-METHALON HYDROCHLORIDE AS INHIBITOR OF MAST CELLS TRYPTASE | 2005 |
|
RU2330034C1 |
| METHODS FOR PREPARING DERIVATIVES OF 1-[2-(BENZIMIDAZOL-1-YL)QUINOLIN-8-YL]PIPERIDIN-4-YLAMINE | 2004 |
|
RU2323214C2 |
| SPIROCYCLIC PYRROLOPYRAZINE(PIPERIDINE)AMIDES AS IONIC CHANNELS MODULATORS | 2012 |
|
RU2634900C2 |
| AMIDES OF CONDENSED PIPERIDINE AS MODULATORS OF ION CHANNELS | 2014 |
|
RU2741810C2 |
| HETEROCYCLIC DERIVATIVES AND USE THEREOF | 2014 |
|
RU2681849C2 |
| HETEROCYCLIC DERIVATIVES AND USE THEREOF | 2015 |
|
RU2734390C2 |
| (6S,9AS)-N-BENZYL-6-[(4-HYDROXYPHENYL)METHYL]-4,7-DIOXO-8-({6-[3-(PIPERAZIN-1-YL)AZETHYDIN-1-YL]PYRIDINE-2-YL}METHYL)-2-(PROP-2-EN-1-YL)-OCTAHYDRO-1H-PYRASINO[2,1-C][1,2,4]TRIAZINE-1-CARBOXAMIDE COMPOUND | 2014 |
|
RU2669805C2 |
