NOVEL CHEMICAL COMPOUNDS - 2,4-DIAMINO-1,3,5-TRIAZINE DERIVATIVES FOR PREVENTING AND TREATING HUMAN AND ANIMAL DISEASES Russian patent published in 2014 - IPC C07D413/12 C07D413/14 C07D471/04 C07D498/04 C07D401/14 C07D513/04 A61K31/5383 A61K31/542 A61K31/4375 A61P35/00 A61P37/00 A61P19/02 

FIELD: chemistry.

SUBSTANCE: invention relates to a 2,4-diamino-1,3,5-triazine derivative of general formula I, having protein kinase inhibitor properties, use thereof and a pharmaceutical composition based thereon. In general formula I Y is CH₂, CHR', O, S, S(O) or S(O)₂; X¹, X², X³ are independently selected from a CH groups or N; R¹ is a C_1-8 aliphatic group, C_3-8 cycloalkyl, C_6-10 aryl, ethylene-dioxyphenyl, methylene dioxyphenyl, pyridyl, each of which is optimally substituted with one or more identical or different groups R"; R' is hydrogen, OH, halogen, such as F, Cl, Br, I, or carboxyl or carboxamide, optimally N-substituted with (C_1-6)alkyl, or cyano or halo(C_1-8)alkyl, (C_1-8)alkoxy, piperidinyl, optimally substituted with methyl; R" is R' or R^D; R²¹, R²², R²³, R²⁴ are independently selected from groups F, Cl, Br, I, CN, (C_1-16)alkyl; furthermore, R²¹ and R²² and/or R²³ and R²⁴ can be combined and represent one oxo (=O) group or together with a carbon atom can form a spirocycle containing 3 to 7 carbon atoms; furthermore, R²¹ and R²⁴ together with two carbon atoms can form an aliphatic or aromatic ring containing 4 to 8 atoms, optionally substituted with one or more groups R'; R^D is an oxo group =O or =S.

EFFECT: invention can be used to treat autoimmune or cancerous diseases, rheumatoid arthritis and non-Hodgkin lymphoma.

13 cl, 12 ex