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2 376 992

(13)

(51)

IPC

A61K31/506(2006-01-01)

C07D239/48(2006-01-01)

C07D401/12(2006-01-01)

C07D403/12(2006-01-01)

C07D405/12(2006-01-01)

C07D407/12(2006-01-01)

(21) (22)

Application

2005105344/04, 2003-07-29

(24)

Start date

2003-07-29

(22)

Actual filing date

2003-07-29

(45)

Published

2009-12-27

(72)

Inventor

Singkh RadzhinderArgade AnkushPehjan Donal'D Dzh.Klaf DzheffriKajm KholgerSilvehn KatrinLi KhuehjBkhamidipati Somasekkhar

(73)

Holder

Rajdzhel Farmas'Jutikalz, Ink.

METHODS OF TREATMENT OR PREVENTION OF AUTOIMMUNE DISEASES BY MEANS OF 2,4-PYRIMIDINDIAMIN COMPOUNDS Russian patent published in 2009 - IPC A61K31/506 C07D239/48 C07D401/12 C07D403/12 C07D405/12 C07D407/12

Abstract RU 2376992 C2

FIELD: medicine.

SUBSTANCE: invention relates to 2,4-pyrimidindiamins, such as N4-(4-Chlorine-3-methoxyphenyl)-5-fluorine-N2-[3-(N-ethylamino)carbonylmethylenoxyphenyl]-2,4-pyrimidindiamin, N4-(3-Chlorine-4-methjopxycarbonylmethylenoxyphenyl)-5-fluorine- N2-[3-(N-methylamino)carbonylmethylenoxyphenyl]-2,4-pyrimidindiamin, N4-[3-Chlorine-4-(N-methylamino)carbonylmethylenoxyphenyl]-5-fluorine-N2-[3-(]N methylamino)carbonylmethylenoxyphenyl]- 2,4-pyrimidindiamin, N4-[3-Chlorine-4-(2-hydroxyethylenoxy)phenyl]-5-fluorine-N2-[3-(N- methylamino)carbonylmethylenoxyphenyl]- 2,4-pyrimidindiamin and other compounds given in item 1 of claimed invention as Syk-kinase inhibitors, as well as to based on them pharmaceutical composition and their application.

EFFECT: claimed compounds can be applied for treatment of autoimmune diseases, systemic http://lingvo.yandex.ru/?text=lupus%20erythematosus, rheumatoid arthritis, etc.

12 cl, 27 dwg, 11 tbl, 1797 ex

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RU 2 376 992 C2

Authors

Singkh Radzhinder

Argade Ankush

Pehjan Donal'D Dzh.

Klaf Dzheffri

Kajm Kholger

Silvehn Katrin

Li Khuehj

Bkhamidipati Somasekkhar

Dates

2009-12-27—Published

2003-07-29—Filed