PRODRUGS OF 2,4-PYRIMIDINE DIAMINE COMPOUNDS AND USE THEREOF Russian patent published in 2011 - IPC C07F9/6561 A61K31/675 A61P37/00 A61P19/02 A61P9/10 A61P21/02 

Abstract RU 2416616 C2

FIELD: chemistry.

SUBSTANCE: invention relates to novel prodrugs of biologically active 2,4-pyrimidine diamine compounds with structural formula given below, hydrate, solvate and pharmaceutically acceptable salts thereof. The compounds have properties for inhibiting cascade transmission of a signal from an Fc-receptor, such as FcαRI, FcγRI, FcγRIII and FcεRI, degranulation or Syk kinase activity. Structural formula:

EFFECT: compounds can be used to treat or prevent rheumatoid arthritis and autoimmune diseases.

25 cl, 21 cl, 6 ex

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RU 2 416 616 C2

Authors

Singkh Radzhinder

Bkhamidipati Somasekkhar

Masuda Ehsteban

Stella Valentino Dzh.

San Tomas

Dates

2011-04-20Published

2006-01-19Filed