FIELD: chemistry.
SUBSTANCE: invention relates to novel prodrugs of biologically active 2,4-pyrimidine diamine compounds with structural formula given below, hydrate, solvate and pharmaceutically acceptable salts thereof. The compounds have properties for inhibiting cascade transmission of a signal from an Fc-receptor, such as FcαRI, FcγRI, FcγRIII and FcεRI, degranulation or Syk kinase activity. Structural formula:
EFFECT: compounds can be used to treat or prevent rheumatoid arthritis and autoimmune diseases.
25 cl, 21 cl, 6 ex
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Authors
Dates
2011-04-20—Published
2006-01-19—Filed