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(19)

(11)

2 510 399

(13)

(51)

IPC

C07K5/10(2006-01-01)

A61K38/07(2006-01-01)

A61P11/14(2006-01-01)

A61P17/04(2006-01-01)

A61P25/04(2006-01-01)

(21) (22)

Application

2009121298/04, 2007-11-13

(24)

Start date

2007-11-13

(22)

Actual filing date

2007-11-13

(45)

Published

2014-03-27

(72)

Inventor

Schteingart Klaudio D.Menzagkhi FrederikeDzhang GuangchengAleksander Roberta VetstsaSueiras-Diaz DzhavierSpenser Robert N.Chalmers Derek T.Luo Zhijong

(73)

Holder

Kara Terapeutiks, Ink

SYNTHETIC PEPTIDE AMIDES AND THEIR DIMERS Russian patent published in 2014 - IPC C07K5/10 A61K38/07 A61P11/14 A61P17/04 A61P25/04

Abstract RU 2510399 C2

FIELD: biotechnologies.

SUBSTANCE: invention refers to ligands in the form of synthetic peptide amides of a kappa-opiate receptor, and namely to agonists of the kappa-opiate receptor, which show a low inhibition degree of P₄₅₀ CYP and a low degree of penetration into brain. According to the invention, synthetic peptide amide is described by the following formula:

EFFECT: pharmaceutical compositions containing the above compounds are suitable for prophylaxis and curing of pain and inflammation, which are related to different diseases and states.

19 cl, 11 dwg, 53 ex

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RU 2 510 399 C2

Authors

Schteingart Klaudio D.

Menzagkhi Frederike

Dzhang Guangcheng

Aleksander Roberta Vetstsa

Sueiras-Diaz Dzhavier

Spenser Robert N.

Chalmers Derek T.

Luo Zhijong

Dates

2014-03-27—Published

2007-11-13—Filed