FIELD: biotechnologies.
SUBSTANCE: invention refers to synthetic peptide amides of formula I
, which are agonists of a kappa-opiate receptor and show a low inhibition degree P450 CYP and lower brain penetration degree. Besides, the invention refers to pharmaceutical compositions containing the above compounds.
EFFECT: possibility of using compounds for prophylaxis and curing of pain and inflammation, which are related to different diseases and states.
17 cl, 9 tbl, 8 dwg, 39 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SYNTHETIC PEPTIDE AMIDES AND THEIR DIMERS | 2007 |
|
RU2510399C2 |
| METHOD OF PRODUCING GLYCOPROTEIN AND SCREENING METHOD | 2009 |
|
RU2520240C2 |
| GLP-1 ANALOGUE DERIVATIVE OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS AND THEREOF APPLICATION | 2010 |
|
RU2565536C2 |
| GLYCATED PEPTIDE GLP-1 | 2009 |
|
RU2543157C2 |
| NEW COMPOSITIONS OF EXENDINE AGONISTS AND METHODS OF THEIR ADMINISTRATION | 2000 |
|
RU2242244C2 |
| METASTIN DERIVATIVES AND APPLICATION THEREOF | 2006 |
|
RU2430107C2 |
| METASTIN DERIVATIVES AND USE THEREOF | 2007 |
|
RU2454425C2 |
| PEPTIDE VECTORS | 2004 |
|
RU2361876C2 |
| HYDANTOIN MODIFIED MELANOCORTIN RECEPTOR LIGANDS | 2008 |
|
RU2450017C2 |
| ANALOGUES OF INSULIN-LIKE GROWTH FACTOR-1 (IGF-1), CONTAINING AMINO ACID SUBSTITUTION IN POSITION 59 | 2010 |
|
RU2511577C2 |
