FORMULATIONS FOR ORAL ADMINISTRATION OF KAPPA-OPIOID RECEPTOR AGONISTS Russian patent published in 2025 - IPC A61K38/07 A61K38/08 

FIELD: medicine.

SUBSTANCE: invention relates to compositions for oral delivery of a kappa-opioid receptor agonist containing CR845 (D-Phe-D-Phe-D-Leu-D-Lys-[ω(4-aminopiperidine-4-carboxylic acid)]-OH) suspended in a solution of capric acid or a capric acid salt in Miglyol; where said CR845 is from 0.1 wt./wt.% to 1 wt./wt.% of the composition, and wherein said solution contains from 70 wt./wt.% to 95 wt./wt.%. Miglyol and from 5 wt./wt.% to 30 wt./wt.% of capric acid or capric acid salt, as well as to a pharmaceutical composition for preventing or treating diseases and pathological conditions associated with a kappa-opioid receptor and a composition for oral delivery of a kappa-opioid receptor agonist, containing CR845 (D-Phe-D-Phe-D-Leu-D-Lys-[ω(4-aminopiperidine-4-carboxylic acid)]-OH), embedded in trehalose, in form of particles suspended in Miglyol or 10 wt./wt.% capric acid in Miglyol.

EFFECT: development of formulations for oral delivery of a kappa-opioid receptor agonist containing CR845 (D-Phe-D-Phe-D-Leu-D-Lys-[ω(4-aminopiperidine-4-carboxylic acid)]-OH.

11 cl, 6 tbl, 113 ex, 14 dwg