ENANTIOSELECTIVE SYNTHESIS OF DERIVATIVES OF GAMMA-AMINO-ALPHA, BETA-UNSATURATED CARBOXYLIC ACIDS Russian patent published in 2014 - IPC C07C227/32 C07C229/30 C07C231/18 C07C269/06 C07C271/12 C07D209/48 C07F9/40 

FIELD: chemistry.

SUBSTANCE: invention relates to method of enantioselective allylic amination of derivatives of α,β-unsaturated carboxylic acids with obtaining enantiomerically enriched derivatives, described by formulae II , III , VII and VIII . Method is performed by interaction of racemic mixture of carboxylic acid derivative with chiral ligand on catalyst [Pd(allyl)Cl]₂ in presence of nucleophilic reagent, selected from potassium phthalimide or amine of formula R1R2NH, where R1 represents benzyl, n-butyl or cyclohexyl group, R2 represents hydrogen or benzyl group.

EFFECT: enantioselective palladium-catalysed ally lamination of derivatives of α,β-unsaturated carboxylic acids with obtaining products with increased enantionmeric excess.

10 cl, 6 dwg, 3 tbl, 48 ex