FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention relates to compounds of formula given below or pharmaceutically acceptable salts thereof. In given formula A is
each of R1-R9 independently represents C, N, O or S; Q is independently selected from C1-6alkyl, halogen, C0-6alkylcarboxylic acid, amino, hydroxy and C1-6alkoxy; n equals 0, 1, 2, 3 or 4 and X represents -OH or 
wherein, if X is -OH, A can not be unsubstituted phenyl. Invention also relates to a pharmaceutical composition, a method for preventive or therapeutic treatment of the above diseases and conditions, use of the disclosed compounds for preparing a medicinal preparation for preventive or therapeutic treatment of the above diseases and conditions, as well as to intermediate compounds used in synthesis thereof.
EFFECT: inventions can be used for preventive or therapeutic treatment of kidney and/or liver fibrosis, for preventing, reducing or decelerating cells death of renal tubules, preventing, reducing or retarding accumulation of fat in liver or restoration of normal tissue structure in a subject.
24 cl, 19 dwg, 1 tbl, 12 ex
или - or
| Title | Year | Author | Number |
|---|---|---|---|
| COMPOSITIONS FOR THE TREATMENT OF HYPERTENSION AND/OR FIBROSIS | 2014 |
|
RU2661878C2 |
| COMPOSITIONS FOR PULMONARY FIBROSIS TREATMENT | 2017 |
|
RU2747801C2 |
| COMPOSITIONS FOR TREATING FIBROSIS AND FIBROSIS-RELATED CONDITIONS | 2016 |
|
RU2712140C2 |
| PYRIMIDINE DERIVATIVES AS INHIBITORS OF PD1/PD-L1 ACTIVATION | 2018 |
|
RU2783211C2 |
| COMPOSITIONS FOR TREATMENT OF HYPERTENSION AND/OR FIBROSIS | 2017 |
|
RU2752088C1 |
| CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | 2008 |
|
RU2479584C2 |
| COMPOSITION FOR TREATMENT OF HYPERTENSION AND/OR FIBROSIS | 2014 |
|
RU2635564C2 |
| CDK4/6 INHIBITOR | 2017 |
|
RU2747311C2 |
| COMPOUNDS OF 1-CYANO-PYRROLIDINES AS USP30 INHIBITORS | 2016 |
|
RU2717238C2 |
| NEW 3-INDOLE SUBSTITUTED DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF APPLICATION | 2016 |
|
RU2672252C1 |
