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2 512 529

(13)

(51)

IPC

C07D405/04(2006-01-01)

A61K51/04(2006-01-01)

A61K101/00(2006-01-01)

(21) (22)

Application

2011118230/04, 2009-10-26

(24)

Start date

2009-10-26

(22)

Actual filing date

2009-10-26

(45)

Published

2014-04-10

(72)

Inventor

Al'Berati DaniehlaBorroni Ehdilio MauritsioKhartung TomasNorkross RodzherPinar Ehmmanjuehl'

(73)

Holder

F.Khoffmann-Lja Rosh Ag

RADIOLABELLED INHIBITORS OF GLICINE 1 TRANSPORTERS Russian patent published in 2014 - IPC C07D405/04 A61K51/04 A61K101/00

Abstract RU 2512529 C2

FIELD: chemistry.

SUBSTANCE: invention relates to novel radiolabelled compounds of formula I in which R¹ represents isopropoxy or 2,2,2-trifluoro-1-methyl-ethoxy; and R² represents radiolabelled CH₃ group, where radionuclide represents ³H or ¹¹C. Invention also relates to pharmaceutical composition for diagnostic visualisation of GlyT1 transporter (glycine transporter type 1).

EFFECT: obtained are novel radiolabelled compounds, which can be applied in medicine as radioactive indicator in PET (positron emission tomography) for labeling and diagnostic molecular visualisation of functionality of glycine transporter type 1.

13 cl, 4 ex

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RU 2 512 529 C2

Authors

Al'Berati Daniehla

Borroni Ehdilio Mauritsio

Khartung Tomas

Norkross Rodzher

Pinar Ehmmanjuehl'

Dates

2014-04-10—Published

2009-10-26—Filed