FIELD: chemistry.
SUBSTANCE: invention relates to novel radiolabelled compounds of formula I in which R1 represents isopropoxy or 2,2,2-trifluoro-1-methyl-ethoxy; and R2 represents radiolabelled CH3 group, where radionuclide represents 3H or 11C. Invention also relates to pharmaceutical composition for diagnostic visualisation of GlyT1 transporter (glycine transporter type 1).
EFFECT: obtained are novel radiolabelled compounds, which can be applied in medicine as radioactive indicator in PET (positron emission tomography) for labeling and diagnostic molecular visualisation of functionality of glycine transporter type 1.
13 cl, 4 ex
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Authors
Dates
2014-04-10—Published
2009-10-26—Filed