FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to new compounds of structural formula I that possess inhibitory activity on phosphatidyl inositol-3-kinase (PI3-kinase). In formula
I: B represents group of formula
II:, wherein Wc represents 6-10-merous aryl, q is equal to 0, 1, 2, 3 or 4; X is absent or represents -(CH(R9))z-, z is equal to 1; Y represents -N(R9)-; Wd represents
R1 and R2 represents C1-6alkyl or halogeno; R3 represents hydrogen or C1-6alkyl; and in each case R9 independently represents hydrogen or C1-6alkyl.
EFFECT: invention refers to a pharmaceutical composition containing the above compounds, and to a method for P3I-kinase inhibition in a subject, wherein the subject suffers a disease representing cancer, a bone disorder, an inflammatory disease, an immune disease, a nervous system disease, a metabolic disease, a respiratory disease, thrombosis or a cardiovascular disease.
24 cl, 11 dwg, 6 tbl, 43 ex
Title |
Year |
Author |
Number |
SOME CHEMICAL STRUCTURES, COMPOSITIONS AND METHODS |
2009 |
- Ren Pingda
- Liu Ji
- Uilson Troj Ehdvard
- Chan Katrina
- Rommel' Kristian
- Li Liansheng
|
RU2537549C2 |
CERTAIN CHEMICAL STRUCTURES, COMPOSITIONS AND METHODS |
2014 |
- Ren Pingda
- Liu Yi
- Wilson Troy Edward
- Chan Katrina
- Rommel Christian
- Li Liansheng
|
RU2716703C2 |
SOME CHEMICAL COMPOUNDS, COMPOSITIONS AND METHODS |
2010 |
- Ren Pingda
- Liu Ji
- Uilson Troj Edvard
- Li Liansheng
- Chan Katrina
- Rommel Kristian
|
RU2582676C2 |
NOVEL COMPOUNDS AND COMPOSITIONS FOR INHIBITION OF FASN |
2014 |
- Bejr Kennet V.
- Lancha Devid R.
- Li Khunbin
- Lok Dzhejms
- Lyu Vej
- Martin Mettyu V.
- Millan Devid S.
- Shiller Shon E.R.
- Tebbe Mark Dzh.
|
RU2686323C2 |
PYRIMIDINE-SUBSTITUTED PURINE DERIVATIVES, PHARMACEUTICAL COMPOSITION BASED THEREON, METHOD OF PROTEIN KINASE INHIBITION, METHOD OF TREATING OR PREVENTING DISEASES SENSITIVE TO PROTEIN KINASE INHIBITION AND METHOD OF TREATING PROLIFERATIVE DISEASES |
2008 |
- Nagaradzh Kharish Kumar Majsur
- Uil'Jams Meredit
|
RU2518098C2 |
PYRIMIDINE-SUBSTITUTED DERIVATIVES OF PURINE, PHARMACEUTICAL COMPOSITION BASED THEREON, METHOD FOR INHIBITING PROTEIN KINASE, METHOD FOR TREATMENT OR PREVENTION OF DISEASES SUSCEPTIBLE TO INHIBITING PROTEIN KINASE, AND METHOD OF TREATING PROLIFERATIVE DISEASES |
2008 |
- Nagaradzh Kharish Kumar Majsur
- Uilyams Meredit
|
RU2681081C2 |
TREATING MALIGNANT TUMOURS USING MODULATORS OF PI3-KINASE ISOFORMS |
2013 |
- Stern Govard M.
- Kutok Dzheffri L.
|
RU2702908C2 |
CHEMICAL COMPOUNDS, COMPOSITIONS AND METHODS |
2010 |
- Ren Pingda
- Liu Yi
- Wilson Troy Edward
- Li Liansheng
- Chan Katrina
- Rommel Christian
|
RU2746319C2 |
N-9-SUBSTITUTED PURINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE |
2010 |
- Kevin Khonlyun Lau
- Vendi Li
- Dzhozef P. Lissikatos
- Chzhonkhua Pej
- Kerk D. Robardzh
|
RU2607635C2 |
QUINAZOLINE DERIVATIVES |
2009 |
- Su Vehj-Guo
- Chzhan Vehjkhan'
- Jan' Sjaotsjan
- Tsuj Jujmin'
- Zhehn' Junsin'
- Duan Tszifehn
|
RU2506261C2 |