SOME CHEMICAL STRUCTURES, COMPOSITIONS AND METHODS Russian patent published in 2014 - IPC C07D217/22 C07D487/04 C07D473/34 A61K31/4725 A61K31/52 A61K31/519 A61P19/02 A61P37/00 A61P11/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to new compounds of structural formula I that possess inhibitory activity on phosphatidyl inositol-3-kinase (PI3-kinase). In formula I: B represents group of formula II:, wherein W_c represents 6-10-merous aryl, q is equal to 0, 1, 2, 3 or 4; X is absent or represents -(CH(R⁹))_z-, z is equal to 1; Y represents -N(R⁹)-; W_d represents R¹ and R² represents C_1-6alkyl or halogeno; R³ represents hydrogen or C_1-6alkyl; and in each case R⁹ independently represents hydrogen or C_1-6alkyl.

EFFECT: invention refers to a pharmaceutical composition containing the above compounds, and to a method for P3I-kinase inhibition in a subject, wherein the subject suffers a disease representing cancer, a bone disorder, an inflammatory disease, an immune disease, a nervous system disease, a metabolic disease, a respiratory disease, thrombosis or a cardiovascular disease.

24 cl, 11 dwg, 6 tbl, 43 ex