PYRIMIDINE-SUBSTITUTED DERIVATIVES OF PURINE, PHARMACEUTICAL COMPOSITION BASED THEREON, METHOD FOR INHIBITING PROTEIN KINASE, METHOD FOR TREATMENT OR PREVENTION OF DISEASES SUSCEPTIBLE TO INHIBITING PROTEIN KINASE, AND METHOD OF TREATING PROLIFERATIVE DISEASES Russian patent published in 2019 - IPC C07D473/32 

FIELD: chemistry.

SUBSTANCE: invention relates to methods for producing a compound of formula (I)

carrying out the reaction of the compounds of formula (II)

with morpholine of formula (III)

hereby obtaining the compounds of formula (I), where R¹ is selected from the group consisting of H, halogen and C₁-C₆ alkyl; R² is selected from the group consisting of H, CN, C₁-C₁₂alkyl, C₃-C₁₂cycloalkyl, C₃-C₁₂cycloalkyl substituted with C₁-C₆alkyl, C₂-C₁₂heterocycloalkyl containing at least one heteroatom, selected from nitrogen, sulfur and oxygen; phenyl, phenyl, substituted C₁-C₆alkyl or halogen; and C₁-C₁₂alkyloxy; R³ and R⁴ each is independently selected from the group consisting of H, C₁-C₆ alkyl and OR⁸; R⁶ is selected from the group consisting of H, NH₂ and NR⁸R⁹; every R⁸ and R⁹ is independently selected from the group consisting of H and C₁-C₁₂alkyl; q is an integer selected from the group consisting of 0 and 1; X represents a group of the formula (CR¹⁰ ₂)_m; every R¹⁰ is independently selected from the group consisting of H and C₁-C₆ alkyl; and m is an integer selected from the group consisting of 0, 1, 2 and 3.

EFFECT: compounds may be useful as drugs for treating a variety of proliferative diseases or disorders, including tumors and cancers, as well as other disorders or diseases associated with PI3K and/or mTOR kinases.

27 cl, 3 tbl