FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to new compounds of formula 
IV, 
VIII-A and 
X, and to their pharmaceutical acceptable salts possessing the inhibitory activity on PI3-kinase (phosphoinositide-3-kinase). In compounds of formula IV and IX and Wd is specified in a group consisting of
, 
, 
, and each of which can be substituted. In formula VIII-A, the group Wd represents the group 
or 
, wherein Ra is hydrogen, R11 is amino; in compound IV, Wa 2 represents CR5; Wa 3 represents CR6; Wa 4 represents N or CR7; in compound IX, Wa 1 and Wa 2 independently represent CR5, N or NR4, and Wa 4 independently represents CR7 or S, wherein no more than two neighbouring atoms in a ring represent atom or sulphur; Wb 5 represents N; B represents a grouping of formula 
II, as well as in case of compound IV, B means C1-C10alkyl, C3-C10cycloalkyl, C3-C10heterocycloalkyl having one to six ring heteroatoms specified in N, O and S; in case of compound IX, B also means C1-C10alkyl, C3-C10cycloalkyl or 6-merous heterocycloalkyl having nitrogen atom; Wc represents C6-C10aryl or 5-18-merous heteroaryl having one or more ring heteroatoms specified in N, O and S, or phenyl or 6-merous heteroaryl respectively is equal to an integer of 0, 1, 2, 3 or 4; X is absent or represents -(CH(R9))z-, respectively; z is equal to 1; Y is absent. The other radical values are specified in the patent claim.
EFFECT: compounds can be used for treating such diseases, as cancer, bone disorders, an inflammatory or immune disease, diseases of the nervous system, metabolic disorders, respiratory diseases, thrombosis or cardiac diseases mediated by PI3-kinase.
68 cl, 11 dwg, 7 tbl, 55 ex
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