N-7 SUBSTITUTED PURINES AND PYRAZOLOPYRIMIDINES, COMPOSITIONS THEREOF AND METHODS FOR USE Russian patent published in 2014 - IPC C07D473/34 C07D487/04 C07D519/00 A61K31/52 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds of formula I, having cell proliferation inhibitor properties. In formula I , Y¹ and Y² each independently denote N or C(R¹), but Y¹ and Y² do not simultaneously denote N or do not simultaneously denote C(R¹), where R¹ is selected from a group consisting of a hydrogen atom, C_1-6alkyl, where R¹ is substituted with 0 or 1 substitutes R^R1, selected from a group consisting of -OR^a; where R^a is selected from a hydrogen atom; R² is selected from a group consisting of a hydrogen atom, C_1-6alkyl; R³ is a 6-7-member monocyclic or bridge heterocycloalkyl ring containing 2 heteroatoms, selected from N and O, where the group R³ is substituted with 0-3 substitutes R^R3, selected from a group consisting of -Rⁱ, Rⁱ is selected from C_1-6alkyl; A¹, A², A³ and A⁴ each denote C(H); and D denotes -NR⁴C(O)NR⁵R⁶, where R⁴ is selected from a group consisting of a hydrogen atom; R⁵ and R⁶ are each independently selected from a group consisting of a hydrogen atom, C_1-6alkyl, C_4-6heterocycloalkyl containing one oxygen heteroatom; and where R⁵ and R⁶ are further substituted with R^D, where R^D is selected from -S(O)₂R^m, where R^m is selected from C_1-6alkyl.

EFFECT: compounds can be used to produce medicine for treating cancer.

21 cl, 1 tbl, 21 ex