SUBSTITUTED 4-(ARYLAMINO) SELENOPHENOPYRIMIDINE COMPOUNDS AND METHODS OF THEREOF APPLICATION Russian patent published in 2015 - IPC C07D517/04 C07D517/14 A61K31/95 A61K31/519 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to selenophene compound of formula (I) or its pharmaceutically acceptable salt. X stands for selenium, Y and Z stand for carbon atoms; or Y stands for selenium, X and Z stand for carbon atoms; or Z stands for selenium, X and Y stand for carbon atoms; A stands for N; B stands for NR⁵, where R⁵ is selected from hydrogen, or alkyl; Ar stands for aryl or heteroaryl ring; aryl represents benzene or naphthalene ring, and heteroaryl represents 6-membered aromatic ring, which contains one, two or three nitrogen atoms; or heteroaryl stands for 5-membered aromatic ring, which contains one or several heteroatoms, selected from sulphur, oxygen and nitrogen, on condition that not more than one oxygen or sulphur atom is present; and such rings include pyridine, pyridazine, pyrazine, pyrimidine, thiophene, furan, pyrrole, pyrazole, imidazole, oxazole, isoxazole, thiazole and isothiazole; optionally substituted with one, two or several groups, independently selected from hydrogen, halogen, thiol, sulphonamide, C_1-6alkyl, secondary C_1-6alkyl, tertiary C_1-6alkyl, C_2-6alkinyl, C_1-4alkoxycarbonyl and phenyl; R¹, R² and R³ are independently selected from hydrogen, carboxylic acid, amino, nitro, cyano, sulphonic acid, thiol, trihalomethyl, C_1-6alkyl, secondary C_1-6alkyl, tertiary C_1-6alkyl, C_1-4alkoxycarbonyl, aminocarbonyl, C_1-6alkylaminocarbonyl, di(C_1-6alkyl)aminocarbonyl, and phenyl; or R¹ and R² are bound, and together with atoms, which they are bound to, they form 5-7-membered optionally substituted carbocyclic or perhydroheterocyclic ring, given in invention formula; or R¹ and R² are bound, and together with atoms, which they are bound to, form optionally substituted aryl or non-substituted heteroaryl ring, fused with selenophene; and aryl represents benzene ring, and heteroaryl represents 6-membered aromatic ring, which contains one nitrogen atom. Methods of obtaining selenophene compound (versions), pharmaceutical composition, methods of treatment or inhibition, or control of cell proliferative disorder are also claimed.

EFFECT: invention makes it possible to obtain selenophene compound, which has anticancer activity.

29 cl, 2 tbl, 35 ex