MORPHOLINO-SUBSTITUTED DERIVATIVES OF BICYCLIC PYRIMIDINE UREA OR CARBAMATE AS MTOR INHIBITORS Russian patent published in 2017 - IPC C07D495/04 A61K31/519 A61K31/5377 A61K31/5386 A61P9/00 A61P25/28 A61P35/00 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to compounds of formula (I) and their pharmaceutically acceptable salts

. I

n formula (I) m is equal to 1; o equals 1 or 2; each R¹ is independently selected from group consisting of H and unsubstituted C_1-6alkyl; two R¹ are possibly combined to form, together with ring, to which they are bonded, 8-oxa-3-azabicyclo[3.2.1]octane-3-yl or 3-oxa-8-azabicyclo[3.2.1]octane-8-yl ring; T¹ is phenyl, where T¹ is substituted by group N(R^5a)C(O)N(R^5bR⁵) and T¹ is optionally additionally substituted with one or more R⁶, which are identical or different; R⁶ is halogen; each of R^5a, R^5b represents H; R⁵ represents H; T²; and C_1-6alkyl, where C_1-6alkyl is optionally substituted with one or more R⁸, which are identical or different; R⁸ represents halogen or OR⁹; R⁹ represents H; T² is unsubstituted and selected from group consisting of phenyl, pyridyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxetanyl or tetrahydrofuranyl; R^a and R^b are selected to obtain one of formulae (Ik)–(Ip)

or R^a, R^b, T¹ are selected to obtain formula (Iq)

R¹⁴, R^14a, R^14b, R^14c are independently selected from group consisting of H; halogen or unsubstituted C_1-6alkyl. Compounds of formula (I) possess mTOR inhibiting activity. Invention also relates to pharmaceutical composition containing compounds of formula (I), use of compounds for making drug and to method of treating.

EFFECT: novel compounds of formula (I) are obtained, which have mTOR inhibitor activity, which can be used for treating or preventing mTOR related diseases and disorders.

16 cl, 15 tbl, 82 ex