PHARMACEUTICAL SALT OF 8-METHYL-7-[5-METHYL-6-(METHYLAMINO)-3-PYRIDINYL]-1-CYCLOPROPYL-4-OXO-1,4-DIHYDRO-3-QUINOLINE CARBOXYLIC ACID, PHARMACEUTICAL COMPOSITION CONTAINING SAME, MEDICINAL AGENT AND METHOD OF TREATING OR PREVENTING BACTERIAL INFECTIONS USING SAID SALTS Russian patent published in 2014 - IPC C07D401/10 A61K31/4709 A61P31/04

Abstract RU 2515557 C9

FIELD: chemistry.

SUBSTANCE: present invention relates to a pharmaceutical salt of 8-methyl-7-[5-methyl-6-(methylamino)-3-pyridinyl]-1-cyclopropyl-4-oxo-1,4-dihydro-3-quinoline carboxylic acid, characterised by that it is in form of a hydrochloride monohydrate and by solubility of at least 0.050 mg/ml water. The invention also relates to a pharmaceutical composition based on said pharmaceutical salt, use of said pharmaceutical salt and a method of treating or preventing bacterial infections based on use of said pharmaceutical salt.

EFFECT: obtaining a novel pharmaceutical salt of 8-methyl-7-[5-methyl-6-(methylamino)-3-pyridinyl]-1-cyclopropyl-4-oxo-1,4-dihydro-3-quinoline carboxylic acid, characterised by good solubility in water, which influences bioavailability of the active ingredient.

7 cl, 16 dwg, 2 tbl, 9 ex

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RU 2 515 557 C9

Authors

Anglada Luis

Palomer Al'Bert

Dates

2014-05-10—Published

2010-04-06—Filed