HEXACYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF AND THEIR USING AS ANTITUMOR AGENTS, METHOD FOR PREPARING HEXACYCLIC COMPOUNDS Russian patent published in 2007 - IPC C07D491/22 A61K31/47 A61P35/00 

FIELD: organic chemistry, chemical technology, medicine, oncology, pharmacy.

SUBSTANCE: invention relates to hexacyclic compounds of the formula [1]: wherein Z represents -NH-C(=X)-N(R¹)- or -N=C(R²)-N(R¹)-; R¹ represents hydrogen atom, (C₁-C₁₀)-alkyl substituted optionally with one-three groups chosen independently from group consisting of (C₁-C₅)-alkoxy-, hydroxy-, amino-, mono-(C₁-C₅)-alkylamino-, di-(C₁-C₅)-alkylamino-group, (C₃-C₇)-cycloalkyl, heterocyclic ring chosen from pyridine or morpholine and aryl wherein aryl ring is substituted optionally with one-three groups chosen independently from group consisting of hydroxy-, alkoxy-group and halogen atom; R² represents hydrogen atom, (C₁-C₅)-alkyl substituted optionally with one-three groups chosen independently from group consisting of (C₁-C₅)-alkoxy-, hydroxy-group, halogen atom and amino-group, (C₁-C₅)-alkoxy-, (C₁-C₅)-alkylthio-, amino-, mono-(C₁-C₅)-alkylamino- and di-(C₁-C₅)-alkylamino-group; each R³ and R⁴ represents independently hydrogen atom or (C₁-C₅)-alkyl; X represents oxygen atom or sulfur atom, and its pharmaceutically acceptable salts. Hexacyclic compounds of the formula [1] possess antitumor activity. Indicated compounds are used in preparing medicinal agents in treatment of cellular proliferative disorders, pharmaceutical composition and in treatment of cellular proliferative disorder. Also, invention relates to methods for synthesis of hexacyclic compounds. Invention provides synthesis of hexacyclic compounds possessing the strong antitumor activity.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition, improved method of synthesis.

31 cl, 1 tbl, 114 ex