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2 517 117

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IPC

A61K38/04(2006-01-01)

A61L27/52(2006-01-01)

A61P25/02(2006-01-01)

B82B1/00(2006-01-01)

(21) (22)

Application

2012150604/15, 2012-11-26

(24)

Start date

2012-11-26

(22)

Actual filing date

2012-11-26

(45)

Published

2014-05-27

(72)

Inventor

Chelyshev Jurij AleksandrovichNikolaev Stanislav IgorevichGalljamov Almaz RafaehlevichRaginov Ivan SergeevichMukhamedshina Jana OlegovnaRizvanov Al'Bert Anatol'EvichSalafutdinov Il'Nur Il'Dusovich

(73)

Holder

Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Meditsinskij Universitet" Ministerstva Zdravookhranenija I Sotsial'Nogo Razvitija Rossijskoj Federatsii Vpo Kazanskij Gmu Minzdravsotsrazvitija Rossii)Federal'Noe Gosudarstvennoe Avtonomnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Kazanskij Federal'Nyj Universitet Kazanskij Federal'Nyj Universitet)Chelyshev Jurij AleksandrovichNikolaev Stanislav IgorevichGalljamov Almaz RafaehlevichRaginov Ivan SergeevichMukhamedshina Jana OlegovnaRizvanov Al'Bert Anatol'EvichSalafutdinov Il'Nur Il'Dusovich

METHOD FOR STIMULATING NEUROTISATION USING NANOSTRUCTURED MATRIX AND GENETIC CONSTRUCTS Russian patent published in 2014 - IPC A61K38/04 A61L27/52 A61P25/02 B82B1/00

Abstract RU 2517117 C2

FIELD: medicine.

SUBSTANCE: conduit wall is presented by a material of random micro- and nanofibres of a bioresorptive polymer of poly(ε-caprolactone), and the content is presented by a self-assembled nanostructured hydrogel of acetyl-(Arg-Ala-Asp-Ala)4-CONH2(PuraMatrix™) oligopeptide. The above conduit is implanted in a complex with the direct local delivery of vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF2) genes to be introduced into the proximal and distal nerve segments, while the formed conduit is implanted into a nerve rupture, and its ends are fixed with epineural sutures.

EFFECT: invention provides a stimulating effect on the invasion of regenerative medullated fibres, on the recovery of motor and sensitive nerve function, and enables improving the effect of the recovery of the nerve structure and function after the extended ruptures.

4 cl

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RU 2 517 117 C2

Authors

Chelyshev Jurij Aleksandrovich

Nikolaev Stanislav Igorevich

Galljamov Almaz Rafaehlevich

Raginov Ivan Sergeevich

Mukhamedshina Jana Olegovna

Rizvanov Al'Bert Anatol'Evich

Salafutdinov Il'Nur Il'Dusovich

Dates

2014-05-27—Published

2012-11-26—Filed