PHARMACEUTICAL COMPOSITION OF IMATINIB OR ITS PHARMACEUTICALLY ACCEPTABLE SALT, METHOD FOR PREPARING IT AND METHOD(S) OF TREATING Russian patent published in 2014 - IPC A61K31/506 A61K47/32 A61K47/38 A61K47/36 A61K9/36 A61K9/58 A61J3/10 A61J3/07 A61P35/02 

Abstract RU 2517216 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to pharmaceutics, namely to a pharmaceutical composition (a solid oral dosage form (a tablet or a capsule)) of tyrosine kinase Bcr-Abl inhibitor - imatinib(4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)-pyrimidin-2-ylamino)phenyl]benzamide). The pharmaceutical composition contains 25-45 wt % of imatinib, preferentially imatinib mesylate, more preferentially an α-crystalline form of imatinib mesylate, a binding agent representing povidone, and at least two desintegrant representing low-substituted hydroxypropyl cellulose and sodium carboxymethyl starch.

EFFECT: invention provides the min 80% imatinib release from the tablet for 15 minutes after oral administration and enables extending the range of drugs used for leukaemia.

14 cl, 4 dwg, 3 tbl, 2 ex

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RU 2 517 216 C2

Authors

Grjaznova Anna Valer'Evna

Khrustaleva Anastasija Olegovna

Dates

2014-05-27Published

2012-08-22Filed